Manager/Associate Director, Antibody Discovery Laboratory

Title:

Manager/Associate Director, Antibody Discovery Laboratory

Job Type:

Regular

Company:

Health Research, Inc. (HRI) Roswell Park Division

Department:

Center for Immunotherapy

Time Type:

Full time

Weekly Hours:

40

FTE:

1

Shift:

First Shift (United States of America)

Summary:

Roswell Park Comprehensive Cancer Center is launching a new antibody discovery initiative to support translational research and therapeutic development in oncology. We are seeking a Manager or Associate Director to help operationalize and lead the newly established Antibody Discovery Laboratory. The selected candidate will be responsible for implementing display-based discovery workflows using a proprietary naïve antibody library and supporting the buildout of a high-functioning lab focused on identifying and characterizing novel binding domains for therapeutic use.

This is a unique opportunity to contribute to the launch and growth of a cutting-edge discovery platform with established institutional support, dedicated lab space, and downstream integration with GMP manufacturing and clinical programs.

Key Responsibilities:
•Support the buildout and daily operations of the antibody discovery lab, including equipment setup, SOP development, and execution of display-based selection campaigns.
•Design and carry out binder discovery workflows targeting oncology-relevant antigens using phage and/or yeast display platforms.
•Perform screening and characterization of hits using ELISA, flow cytometry, affinity measurements, and other relevant analytical tools.
•Document and present experimental findings, and contribute to candidate triage and transfer for downstream applications (e.g., cell therapy, bispecifics).
•Collaborate with other research, manufacturing, and clinical teams to support translational development.
•Help recruit and train junior technical staff and ensure adherence to best practices and compliance standards.

Salary range for this position is $39,900-$185,000 annually which includes comprehensive benefits package.

Qualifications:

Required Education and Experience

1. M.D. or PhD in an appropriate field; or
2. Master’s degree in an appropriate field.

NOTE:
Required degrees must have been granted by an accredited school, college or university or one recognized by Roswell Park Comprehensive Cancer Center as following acceptable educational practices.

Preferred Qualifications

The ideal candidate should have a Ph.D. or M.S. in Molecular Biology, Immunology, Protein Engineering, or a related field, and at least 3 years of experience in antibody or protein binder discovery using display technologies. The ideal candidate will have hands-on expertise in panning, screening, and binder characterization workflows, along with strong organizational, problem-solving, and communication skills. The ability to work independently while thriving in a fast-paced, collaborative research environment is essential. Experience in therapeutic antibody development and/or immuno-oncology applications is highly desirable. Familiarity with display library construction and developability assessments is a plus, as is a background in translational or GMP-adjacent environments.

Equal Employment Opportunity Statement

Roswell Park Cancer Institute Corporation (RPCIC) and Health Research Inc. (HRI) Roswell Park Division believe that all persons are entitled to equal employment opportunities, and we do not discriminate against our employees, applicants or job seekers because of their race, color, religion, sex, sexual orientation, gender identity or expression, national origin, creed, age, disability, pregnancy-related condition, military or veteran status, marital or familial status, domestic violence victim status, citizenship status, genetic information, individual’s relationship or association with a member of a protected category or any other protected group status as defined by law.

Affirmative Action/Equal Opportunity Employer/Qualified Individuals with Disabilities/Qualified Protected Veterans

Reasonable Accommodation Request

RPCIC and HRI are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the employment process, please email HR-PayAndBenefits@RoswellPark.org