Principal Scientist - Toxicology - Global Discovery & Development Sciences

About the Department                                                                                                                                               

Our Research & Development organization brings together the best minds in life science innovation. The teams located in facilities in Lexington, Watertown, Cambridge and Seattle reflect the full R&D continuum, from early research through late-stage clinical development. Here, we are building for the future, creating a distinct R&D community based on collaboration, partnerships, and cutting-edge research across multiple modalities and therapeutic areas. We recognize that improving human health starts here and that patients rely on us. Our R&D hub merges biotech speed and agility with large pharmaceutical company quality, resources, and stability, uniting the best of both worlds to develop new medicines for patients.

 

Global Discovery and Development Sciences (GDDS) Boston, part of the US R&D hub, is building a new siRNA Nonclinical Development department with cross-functional scientific expertise, including toxicology, safety pharmacology, PKPD, ADME, outsourcing management, and non-clinical project management. The department manage the nonclinical development process from lead candidate selection to submission and registration of new siRNA-based therapies within our core business areas, including diabetes, obesity, cardiovascular disease, metabolic dysfunction-associated steatohepatitis and chronic kidney disease, and rare diseases. Our proprietary GalXC™ and GalXC-Plus™ siRNA technologies have the potential to selectively target and modulate proteins that cause or contribute to the disease and thereby address conditions that are difficult or impossible to treat with other modalities. The team is located in Lexington in close proximity to our Discovery and Development teams to facilitate collaboration and knowledge transfer throughout the lifecycle of a project.

 

About the Department

Our US Research & Development (R&D) hub, located in the Greater Boston area, brings together the best talent to drive life science innovation, from early research through late-stage clinical development. By combining the speed and agility of biotech with the quality, resources, and stability of a large pharmaceutical company, our US R&D hub will benefit from the best of both worlds to develop new medicines that meet the needs of patients.

 

Global Discovery and Development Sciences (GDDS) Boston, part of the US R&D hub, is building a new siRNA Nonclinical Development department with cross-functional scientific expertise, including toxicology, safety pharmacology, PKPD, ADME, outsourcing management, and non-clinical project management. The department manage the nonclinical development process from lead candidate selection to submission and registration of new siRNA-based therapies within our core business areas, including diabetes, obesity, cardiovascular disease, metabolic dysfunction-associated steatohepatitis and chronic kidney disease, and rare diseases. Our proprietary GalXC™ and GalXC-Plus™ siRNA technologies have the potential to selectively target and modulate proteins that cause or contribute to the disease and thereby address conditions that are difficult or impossible to treat with other modalities. The team is located in Lexington in close proximity to our Discovery and Development teams to facilitate collaboration and knowledge transfer throughout the lifecycle of a project.

 

The Position

Our new growing siRNA Nonclinical Development department is looking for a Principal Toxicologist to provide scientific leadership and be responsible for the siRNA nonclinical development toxicology strategy and its implementation. The Principal Toxicologist will be part of a highly ambitious multi-disciplinary team dedicated to challenge and optimize the way we do siRNA nonclinical development to ensure timely and adequate nonclinical regulatory documentation, safety assessments, and clinical trial support for our siRNA projects. The Principal Toxicologist will be responsible for the design and execution of nonclinical development toxicology studies conducted externally, interpretation and communication of the toxicology data/reports to support drug development decisions, and for summarizing and writing regulatory submissions. The Principal Toxicologist will work closely with the Nonclinical Study Managers which will help to oversee and manage the outsourced noncl