Staff Product Security Engineer #4612

Our mission is to detect cancer early, when it can be cured. We are working to change the trajectory of cancer mortality and bring stakeholders together to adopt innovative, safe, and effective technologies that can transform cancer care.
We are a healthcare company, pioneering new technologies to advance early cancer detection. We have built a multi-disciplinary organization of scientists, engineers, and physicians and we are using the power of next-generation sequencing (NGS), population-scale clinical studies, and state-of-the-art computer science and data science to overcome one of medicine’s greatest challenges.
GRAIL is headquartered in the bay area of California, with locations in Washington, D.C., North Carolina, and the United Kingdom. It is supported by leading global investors and pharmaceutical, technology, and healthcare companies.
For more information, please visit grail.com
GRAIL is seeking a mission-driven and high-impact Staff Product Security Engineer to serve as a technical cornerstone for product security initiatives across the company. Reporting to the Director of Product Security, this role plays a critical part in enabling secure, resilient products that support GRAIL’s life‑saving mission.As a Staff-level individual contributor, you will lead the technical execution of the Product Security roadmap, partner closely with Engineering and Product teams, and mentor other security engineers. You will influence architecture and development decisions across the product lifecycle, helping teams navigate an evolving threat landscape while maintaining delivery velocity in a regulated environment.
Flexible – Menlo Park (MPK) – 3 days in officeThis role is based in Menlo Park, California, and will move to Sunnyvale, California in Fall 2026. GRAIL offers a flexible work arrangement, with the ability to work from GRAIL's office or from home. Our current flexible work arrangement policy requires that a minimum of 60%, or 24 hours, of your total work week be on-site. Your specific schedule, determined in collaboration with your manager, will align with team and business needs and could exceed the 60% requirement for the site.

Responsibilities

• Lead product security architecture and security-by-design practices across the full product lifecycle, from concept through post‑market support.
• Embed security into the Secure Software Development Lifecycle (SSDLC) and DevSecOps pipelines, establishing guardrails that balance risk reduction with engineering velocity.
• Perform and guide threat modeling, security risk assessments, and architecture reviews across products and enterprise‑connected systems.
• Define and enforce security controls for AI- and ML-enabled products, including data protection, model integrity, access controls, and secure pipelines.
• Manage, and operate Product Security post-market surveillance activities across GRAIL products and services, from intake through remediation and closure.
• Influence secure solution architectures for GRAIL ecosystems, considering system integration, access control (IAM), key management (KMS), secure data flows, resilience, patch management, and recovery.
• Scope, oversee, and review penetration testing and advanced security testing activities across software, systems, and infrastructure.
• Serve as a product security subject matter expert during incident response, root cause analysis, and post‑incident improvements.
• Partner with Product, Engineering, Quality, Legal, and other stakeholders to ensure alignment with regulatory and industry cybersecurity requirements.
• Define, track, and report product security metrics and KPIs to provide visibility into security posture and risk trends.
• Mentor and coach engineers, contributing to the growth of product security capabilities and future technical leaders at GRAIL.
These responsibilities summarize the role’s primary responsibilities and are not an exhaustive list. They may change at the company’s discretion.

Required Qualifications

• 8+ years of experience in product security, cybersecurity, application security, or related technical security roles.
• Hands-on experience leading threat modeling, security risk assessments, and vulnerability management for complex software products.
• Experience embedding security into modern software development environments, including CI/CD and DevSecOps practices.
• Experience supporting security incident response and conducting root cause analysis in production environments.
• Bachelor’s degree in Cybersecurity, Computer Science, Information Systems, or a related field, or equivalent practical experience.

Preferred Qualifications

• Experience working in regulated environments, including medical devices, hea