Advisor/Sr. Advisor - Macrocycles Chemical Biology

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Protomer team at Lilly focuses on chemical biology, molecular switches and (oral) peptidic macrocycles platforms. This position is focused on deep technology development in chemical biology, specifically peptides and macrocycles with a particular focus on peptide libraries, and oral macrocyclic peptides.   

The Protomer team engages in disease-relevant biological systems in order to test preclinical and clinical pipeline of innovative medicines. The candidate is expected to help develop strategy, direction and manage scientific group milestones and objectives based on an ambitious long-term strategic plan which the candidate helps to develop.  

The ideal candidate is a significant contributor and leading a highly integrated, agile, and collaborative team effort and expected to manage the scientific portfolio, the business supporting the portfolio, and mentoring of junior scientists within the oral macrocycles group at Protomer. Ideal candidate is expected to have demonstrated success in similar roles with proven track record of leading both scientific rationale, planning and execution leading to success in making medicines. 

This individual will also be expected to be able to independently lead projects, help shape the team and strategy of the group, contribute significantly to prioritization of the team objectives and interact with and create and nurture the cross-functional relationships interacting with various therapeutic areas such diabetes and obesity, neuroscience, immunology and oncology. 
 
Responsibilities: 

• Contribute to projects in oral macrocycles, chemical biology or peptide frameworks combining aspect of molecule design and conjugation at the interface of small molecules and peptides.
• Work on (both directionally and operationally) molecule engineering efforts from lead identification to lead optimization and contribute along the way to phase 1b and beyond. 
• Lead display screening efforts from lead finding to lead optimization of oral macrocyclic peptide discovery projects
• Learn about and enhance the platform technology efforts at Protomer to accelerate the lead finding and optimization process.
• Work collaboratively in the group to achieve a common goal but also provide independent perspective and scientific rationale and contribute to strategy and execution.  
• Take on dedicated molecular engineering efforts towards targets of high conviction and use speed and prioritization to advance synthetic efforts both at Protomer and wider Lilly groups and through collaboration with the rest of LRL. 
• Inspire people to collaborate in inventing great medicines by removing barriers, committing to high quality scientific hypotheses, and accelerating where possible. 
• Keep safety as a top priority at all times, striving toward a proactive safety culture. 
• Be an advocate for diversity and inclusion in our recruiting, retaining and developing scientists, with a commitment to coaching and development of scientists. 
• Be a good teammate and work effectively, responsibly and professionally with colleagues at Protomer and across Lilly.  

 
Qualifications: 

PhD or post-doctoral degree in chemistry, synthetic chemistry, chemical biology or related field with significant experience in these fields and a proven track record of research success.  ·