Associate Scientist - Technology Development and mRNA Sciences
Eli Lilly and CompanyAbout the role
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
Organization Overview
Verve Therapeutics, a wholly owned subsidiary of Eli Lilly & Company within Lilly Research Labs, is a clinical-stage genetic medicines company established with a mission to solve the global health epidemic of cardiovascular disease. Founded by world-leading experts in cardiovascular medicine, human genetics and gene-editing, Verve is pioneering a new approach to the care of cardiovascular disease, potentially transforming treatment from chronic management to single-course gene editing medicines. The company’s initial three programs – VERVE-101, VERVE-102, and VERVE-201 – target genes that have been extensively validated as targets for lowering low-density lipoprotein cholesterol (LDL-C), a root cause of cardiovascular disease. VERVE-101 and VERVE-102 are designed to permanently turn off the PCSK9 gene in the liver and are being developed initially for heterozygous familial hypercholesterolemia (HeFH) and ultimately to treat atherosclerotic cardiovascular disease (ASCVD) patients not at goal on oral therapy. VERVE-201 is designed to permanently turn off the ANGPTL3 gene in the liver and is initially being developed for homozygous familial hypercholesterolemia (HoFH) and ultimately to treat patients with refractory hypercholesterolemia. In 2024, Verve was named a Top Place to Work by The Boston Globe for the fourth consecutive year. Verve is headquartered in Boston, Massachusetts.
Help us expand the scope of what gene editing can accomplish by tapping into your expertise in molecular and biochemical techniques to develop novel CRISPR-based technologies. We will use pioneering equipment to design, create, and test nucleic acid-based constructs alongside PhD level teammates with combined 40+ years of industry and academic experience. This highly cross-functional role requires an individual who wants to broaden their expertise across various scientific disciplines by simultaneously collaborating with multiple departments within and outside of the organization.
A successful candidate will be one who is motivated by curiosity, a desire to inspire others, and contribute to technology development efforts. Mechanistic understanding of gene regulatory circuits and ability to think at the systems biology level to control expression will prove indispensable for this role. We will be spending 90% of our time on site, where you will work alongside your mentor to design and implement experiments. It is expected that the candidate exhibit a growth mindset and begin to generate their own own hypotheses, eventually taking ownership of projects as they progress through their career.
Responsibilities
Investigate methods for precision-based genome editing tools
Knowledge of gene regulation and gene regulatory elements is a plus
Contribute to the design, production, and analytical characterization of mRNA constructs to improve efficacy, safety, and stability
Perform routine cell culture and
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