Senior Director, ADC Process Development

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Overview:

We are seeking a Senior Director, ADC Process Development, to lead and expand our growing team of scientists and engineers focused on delivering Lilly’s Antibody-Drug Conjugate (ADC) portfolio. This role will be responsible for driving the end-to-end development of small molecule payloads, linkers, and conjugation processes from preclinical through commercial. This is a high-impact role that sits at the critical intersection of chemistry, engineering, and biologics, requiring technical excellence, strategic oversight, and strong team leadership. 

Position Summary:

The ideal candidate will bring deep expertise in small molecule process chemistry, combined with a strong track record of leadership in cross-functional and matrixed environments. This position plays a critical role in building a world-class ADC platform and advancing Lilly’s pipeline of innovative medicines.

Key Responsibilities include: 

• Build and lead a multidisciplinary team of scientists and engineers, managing resources to meet project and program objectives. 

• Develop and implement short- and long-term CMC strategies to support a growing portfolio pipeline, while balancing internal and external resource requirements and constraints. 

• Collaborate with internal stakeholders (e.g., Discovery, Analytical, Drug Product, Quality, Regulatory, CMC PM) and external CDMOs to align and execute the CMC development plan. 

• Create and update end-to-end capacity models, provide important data for business planning.  

• Drive the design, scale-up, and tech transfer of small molecule payload and linker synthesis processes in support of ADC development.  

• Oversee development and optimization of conjugation processes for early and late-stage clinical projects. 

• Work with HSE to establish and enforce safety protocols for handling ADC payloads, linkers, and conjugates in development labs. 

• Contribute to regulatory submissions (IND, IMPD, BLA/MAA), authoring high-quality CMC sections. 

• Help drive innovation and evaluate emerging technologies to enhance platform capabilities.  

Basic Requirements:

• Ph.D. and M.S. in Organic Chemistry, Chemical Engineering, Pharmaceutical Sciences, or related discipline. 

• A minimum of 8 years of industry experience (with a Ph.D.) or 15 years (with an M.S.) in small molecule process development. 

• Demonstrated experience leading technical teams and managing people, ideally across multiple functions. 

• Strong track record of successful IND/IMPD/BLA submissions and regulatory interactions. 

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