Contract Principal Scientist

Overview

Replimune’s mission is to revolutionize cancer treatment with therapies designed to activate a powerful and durable full-body anti-tumor response, boldly transforming cancer care because patient’s lives depend on it. We imagine a world where cancer is a curable disease. 

 At Replimune, we live by our values: 

United: We Collaborate for a Common Goal. 

Audacious: We Are Bold and Innovative. 

Dedicated: We Give Our Full Commitment. 

Candid: We Are Honest With Each Other. 

People are at the center of everything we do, and when it comes to our employees, we make it personal.  With a deep sense of purpose, an innovative and collaborative culture, a competitive and forward-looking total rewards program, everyone at Replimune has a unique opportunity to contribute to the meaningful work we do which could impact the lives of patients.  

 Join us, as we reshape the future. 

 

Job Summary: 

Reporting into the Executive Director of Translational Research, the Principal Scientist will be responsible to develop and execute translational research strategy for one or more of Replimune’s clinical programs. The candidate will contribute to the overall translational strategy of pre-clinical and clinical biomarker development. The candidate should be able to use bioinformatic platforms to analyze biomarker data in conjunction with clinical responses. The candidate will participate in team meetings and communicate on status and progress of biomarker sample collection and testing and oversee sample management from the clinical site to the central labs and to the testing lab in collaboration with Clinical Operations. The candidate will perform data analysis and generate reports from Replimune’s translational research studies including from both pre-clinical and clinical trials. The candidate will also support key activities in translational research aimed at helping to elucidate the underlying mechanisms of action of Replimune’s product candidates, and to characterize the pharmacokinetic and pharmacodynamic effects. This is a non-lab-based role and will largely manage translational studies at central labs, contract research organizations (CROs) and other specialty labs performing translational research studies.

 

Please note that this is a fixed-Term contract postion for a period of up to one (1) Year. 

This position is based in our Woburn office and welcomes hybrid work! Local candidates are expected to be on-site 2 days per week.

Responsibilities

 

• Develop and execute translational research strategy for one or more of Replimune’s ongoing clinical and pre-clinical programs
• Develop strategies to integrate different data modalities, including NGS, single-cell transcriptomes, digital pathology, with clinical observations to derive mechanistic and biomarker insights
• Collaborate with, and manage CROs to identify predictive biomarkers with an emphasis on the development and validation of pharmacodynamic assays to support ongoing clinical and pre-clinical studies
• Process images from immuno-histochemistry assays and identify feasible ways to quantify the staining of the slides. Develop and analyze data tables, graphs and reports from gene expression analyses, clinical pharmacokinetic studies and other translational research studies.
• Maintain project timelines for translational and clinical pharmacokinetic studies and facilitate sample testing to meet deadlines for abstract presentations and manuscript submissions.
• Perform correlative analysis of biomarker data with patient responses in collaboration with clinical development and biostatistics.
• Work closely with the clinical operations, external collaborators, and contract research organizations (CROs) to execute translational research studies.
• Act as a liaison to transfer translational research related assays between internal and external labs.
• Author the biomarker sections of Investigator Brochures, clinical study protocols and reports, program documents, regulatory submissions and responses (INDs/CTAs), and relevant pharmacology sections of regulatory documents
• May be asked to sit on study specific project team meetings and present translational research data as necessary.

 

 

Other responsibilities

• Perform a variety of tasks, duties and responsibilities as assigned from time to time

Qualifications

Education:   

• Master’s degree in molecular biology or immunology with 7-8 years of relevant experience or Ph.D. with 2-3 years. Prior industry exper