Scientist – In Vitro High-Content Imaging Assay Development and Execution Supporting siRNA Programs

Career Category

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions.

As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist – In Vitro High-Content Imaging Assay Development and Execution Supporting siRNA Programs

What you will do

Let’s do this. Let’s change the world. In this vital role you will partner closely with the Genetic Medicine team and cross-functional collaborators, including teams in molecular biology, bioinformatics, therapeutic areas, and automation/engineering, to translate screening data into prioritized siRNA candidates and downstream characterization plans. This role requires independently leading discovery assays, owning automation activities, and driving cross-functional experimental strategy.

You will support Amgen’s siRNA drug discovery and development pipeline, with a primary focus on developing high-throughput, cell-based assays for the quantitative measurement of gene transcription to screen siRNA libraries and identify potential therapeutic candidates.

Key Responsibilities:

· Design, develop, and validate quantitative cell-based transcriptional assays (high-content RNA FISH, qRT-PCR) suitable for HTS/automation.

· Implement assay miniaturization and automation workflows with HTS platforms; collaborate with automation engineers to deliver reproducible, high throughput runs.

· Independently lead multiple screening projects and deliver high quality data, interpret results, and coordinate follow-up validation experiments.

· Proactively participate in siRNA program meetings, communicate results and technical recommendations to Genetic Medicine and therapeutic-area partners, drive decisions for candidate progression.

· Contribute to siRNA delivery, uptake and cellular localization by utilizing high-content Imaging assays and automation platforms.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The Scientist we seek is a motivated researcher with these qualifications.

Basic Qualifications:

Doctorate degree
 

OR
 

Master’s degree and 2 years of In Vitro High-Content Imaging Assay Development experience
 

OR
 

Bachelor’s degree and 4 years of In Vitro High-Content Imaging Assay Development experience

Preferred Qualifications:

• Excellent cell culture techniques
• Experience with siRNA transfection and RNA FISH assays
• High-content imaging assay development using Opera Phenix
• Familiarity with lab automation instruments
• Strong critical thinking and troubleshooting skills

What you can expect from us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disa