Associate Principal Scientist, Biochemistry - Mass Spectrometry & Biophysics Department

Job Description

Job description

At our company, we are committed to improving the health and well-being of people around the world. As a leading global pharmaceutical company, we strive to make a difference through innovative research, discovery, and development of life-saving medications and vaccines. With over a century of experience and a steadfast dedication to scientific excellence, we have become a trusted name in the industry. Join our team and be a part of our mission to create a healthier future for all.

We are seeking a highly motivated and innovative Associate Principal Scientist to join our Biochemistry & Mass Spectrometry team within the Mass Spectrometry & Biophysics (MSB) Department in Quantitative Biosciences. Our team utilizes multidisciplinary techniques to characterize ligand-protein interactions and modulation of (target) protein function to support early-stage drug discovery across a broad spectrum of therapeutic modalities.

Applicants will ideally have a strong background in biochemistry and prior experience in assay development, including assays utilized to progress targeted protein degradation (TPD) drug discovery. The successful candidate will be part of cross-functional teams and will collaborate across diverse therapeutic areas including Oncology, Immunology, Neuroscience, Cardiometabolic and Infectious Diseases.

Key Responsibilities:

• Design, develop and execute biochemical assays supporting all stages of drug discovery with an emphasis on induced proximity and protein degradation.

• Stay abreast of advancements in the field of induced proximity & protein degradation.

• Drive innovation through platform development, internal/external collaboration & long-range capability planning.

• Contribute to the development of biochemical assays supporting high-throughput screening, hit validation & hit-to-lead activities as required.

• Serve as a representative on cross-functional program teams with accountability for delivering progress updates, presenting data & contributing to strategic direction.

• Contribute to a high-performance culture of inclusion, collaboration, engagement, and self-accountability.

• Promote the external reputation of our department through publications and participating in external symposia.

Minimum Education Required:

• Post-graduate degree in Biochemistry, Pharmacology, Biology, or another related field with 4+ years of relevant industry experience: Ph.D. (4+ years), M.Sc. (7+ years) or B.Sc. (12+ years).

Essential Qualifications:

• Experience in biochemical assay development across a broad range of technologies (e.g., fluorescence- and luminescence-based technologies) to assess protein-ligand interactions, modulation of enzyme function (inhibition; activation) and mechanism-of-action.

• Prior experience developing in vitro assays to progress targeted protein degradation drug discovery, including assessment of compound-dependent ternary complex formation efficiency, cooperativity, and functionality (e.g. substrate ubiquitylation).

• Prior experience serving as a departmental representative on cross-functional drug discovery teams.

• Experience performing technology evaluations & making recommendations on investments designed to maintain a leadership position in the field.

• Demonstrated passion for fostering a diverse and inclusive culture and contributing to the growth and success of colleagues.

• Strong external reputation as evidenced through high-impact publications, presentations, and scientific community engagement.

• Excellent verbal, written and interpersonal communication skills with a proven track-record of maintaining strong relationships with stakeholders.

Desirable Experience and Skills:

• Expertise in biophysical methods (SPR, ITC, MST, thermal shift assays, etc.) is advantageous.

• Prior experience developing assays supporting high-throughput screening for enzyme inhibitors/activators, protein-protein interaction disruptors, etc. is beneficial.

• Experience working with automated liquid handling instruments and platforms (ECHO, BRAVO, etc.) is advantageous.

• Experience with Western Blot techniques, including use of high-throughput/automated systems (ProteinSimpleTM), is desirable.

NOTICE FOR INTERNAL APPLICANTS

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