Scientist II Process Chemistry, Biocatalysis

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on X, Facebook, Instagram, YouTube, LinkedIn and Tik Tok.

Job Description

The Process Chemistry group is responsible for inventing and executing the chemical processes and preparing active pharmaceutical ingredients (API) to enable toxicology studies, clinical trials, and drug product development for AbbVie’s pre-clinical and clinical candidates. We create valuable intellectual property through composition of matter, chemical processes, and technology, resulting in the development of safe and cost-effective commercial manufacturing processes.

AbbVie Process Chemistry is seeking a highly motivated Chemist with expertise in Biocatalysis to conduct chemical process research and development, supporting projects from pre-clinical stages through commercialization. 

Responsibilities:

• Identify and propose diverse biocatalytic transformations to improve the synthesis of small molecules. Develop a sound experimental approach to investigate the proposed transformations.
• Design and conduct high throughput experiments (HTE) to support the discovery of potential biocatalysts for small molecule transformations, use medium-throughput experimentation (MTE) tools for reaction optimization.
• Develop robust biocatalytic processes that consistently deliver high-quality products with excellent yields.
• Interpret results and draw conclusions from experiments, note significant deviations, and propose, design, and execute relevant follow-up experiments.
• Exhibit high independence and productivity in laboratory research or method development.
• Develop new tools and protocols for biocatalysis, including new transformations,    protein redesign, troubleshooting, and robustness studies for novel solutions.
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