Postdoctoral Fellow-MSH-30040-223

Title: Postdoctoral Position – Epigenetics of Lung Diseases

Department: Pharmacological Sciences

Physical work location: (must be proper street address): 1 Gustave L Levy Place. NY 10029

Name PI or Supervisor: (include phone and email): Lahouaria Hadri Lahouaria.hadri@mssm.edu

Web link to Lab: https://labs.icahn.mssm.edu/hadrilab

Web link to Department: https://icahn.mssm.edu/about/departments/pharmacological-sciences

Administrative Contact: (phone and email): Yoori Kim, 212-6598651, yoori.kim@mssm.edu

Details of Research Project: 

We are seeking a highly motivated and independent Postdoctoral Fellow to lead hypothesis-driven research focused on the epigenetic and transcriptional regulation of heart and lung vascular diseases. This position is ideally suited for a candidate with a strong background in epigenetics, chromatin biology, vascular biology, or molecular cardiopulmonary research.

The successful candidate will join a dynamic, multidisciplinary research team and contribute to projects aimed at uncovering novel molecular mechanisms underlying pulmonary hypertension, cardiac remodeling, and other lung vascular pathologies. Our work integrates basic and translational science with the goal of identifying therapeutic targets.

Technical Duties:

• Design and conduct molecular and cellular experiments focused on cardiopulmonary disease mechanisms using Primary cell cultures (e.g., endothelial cells, smooth muscle cells), Animal models of vascular and cardiopulmonary disease, Human tissue samples, where applicable, drug screening, and Gene Therapy.
• Apply next-generation sequencing (NGS) techniques, including: ATAC-seq, ChIP-seq, CUT&RUN, RNA-seq, and single-cell omics
• Perform multi-omics data analysis, including epigenomic and transcriptomic profiling.
• Interpret and present research findings in lab meetings, seminars, and at national/international scientific conferences.
• Prepare and submit manuscripts to high-impact, peer-reviewed journals.
• Contribute to the preparation of research grant proposals and progress reports.

Educational and other Requirements for the position: 

Experience Required:

• Ph.D. in Molecular Biology, Epigenetics, Genomics, or related field.
• Strong background in epigenetic regulation and molecular biology techniques.
• Strong publication record in relevant areas.
• Familiarity with animal models of disease and in vivo functional studies.
• Basic to intermediate skills in bioinformatics and statistical analysis of omics data (e.g., R, Python, or other tools).
• Ability to work independently and manage multiple projects simultaneously.
• Excellent scientific writing, communication, and collaboration skills.

We offer

• A stimulating research environment within the lab and the department, a collaborative and well-funded laboratory.
• Access to state-of-the-art core facilities and high-throughput sequencing platforms.
• Mentorship focused on career development and transition to academic faculty or industry leadership.
• Opportunities to contribute to high-impact publications and high-profile collaborative projects.

Goals/Outcomes of the Research Project:

• Elucidate Epigenetic Mechanisms in cardiopulmonary Disease Pathogenesis and identify key epigenetic alterations that contribute to the development and progression of chronic lung diseases such as pulmonary fibrosis and PAH.
• Integrate Multi-Omics Datasets: Combine epigenomic data with transcriptomic, proteomic, or clinical datasets to build comprehensive molecular profiles and identify therapeutic targets.
• Evaluate the Therapeutic Potential of Epigenetic Modulators using drug and gene therapy.
• Disseminate Novel Findings: Publish results in high-impact peer-reviewed journals, present findings at national and international conferences.
• Advance Career Development and Support the postdoctoral fellow in developing independent research skills, securing fellowships or early-career grants, and building a professional network for future academic or industry roles.

If you are interested in applying for the position, please email your CV and 3 letters of reference to Lahouaria Hadri at lahouaria.hadri@mssm