Executive Director, Clinical Development

Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit frontier targets in RAS-addicted cancers.  The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

We have an opportunity for experienced drug developer and with extensive/exceptional pharma/biotech experience to serve as Principal Exceutive Director of Clinical Development in support of Revolution Medicines’ clinical-stage molecule(s) and/or pre-clinical molecule(s). In this critical role, you will be responsible for developing the strategic plans and ensuring efficient operational execution of the molecule(s)’ clinical development program in one or more disease indications, from early-stage studies to regulatory submissions and potential commercialization. You will play a pivotal role in shaping the future of our pipeline and driving the development of transformative therapies for patients.

• Provide critical insights/contributions and implement comprehensive/execute upon the clinical development plans for Revolution Medicines’ molecules, ensuring alignment with scientific, regulatory, and commercial objectives.

• Lead, mentor, and manage a high-performing cross-functional team of clinical development professionals, fostering a culture of collaboration, innovation, and excellence.

• Oversee all aspects of clinical trial design and execution, including site selection, patient recruitment, data management, and regulatory compliance.

• Establish and maintain strong relationships with clinical investigators, regulatory agencies, and key stakeholders.

• Gather, analyze and interpret clinical data, providing strategic insights to inform critical decisions and guide program development.

• Manage clinical development timelines effectively, ensuring efficient resource allocation and achievement of milestones.

• Stay abreast of the latest scientific advancements and regulatory trends in the field of clinical development.

• Partner with cross-functional teams, including research, regulatory affairs, commercial, and finance, to ensure seamless program execution and achieve shared goals.

Required Skills, Experience and Education:

• MD, PhD or similar biomedical graduate degree with 15 or more years experience in pharmaceutical/biotech industry

• Extensive pharmaceutical or biotech industry experience with both internal and external reputation as a scientific/development thought leader

• Has contributed major advances to a disease area as evidenced by direct involvement in the creation of clinical development strategies that have result in label-enabling outcomes and publications in top tier journals.

• Extensive experience working with the principles and techniques of data analysis, interpretation, and clinical relevance as related to the pharmaceutical/biotech industry

• Extensive experience designing and conducting multiple clinical trials as part of a wider clinical development programs from early-stage to late-stage, across multiple disease indications and/or therapeutic areas

• Experience authoring a clinical development strategy is required

• Extensive understanding of medical aspects of GCP (Good Clinical Practice), ICH (International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use), FDA, EMA, and other relevant guidelines and regulations

• Has led or oversaw other clinical development scientists, regulatory and other internal partners through major and varied Health Authority interactions (e.g. FDA, EMA, others). Has led or overseen other in Health Authority interaction(s)

• Experience submitting an NDA/BLA/MAA to global health authorities

• Strong orientation to teamwork. Has consistently excelled as a cross-functional leader. Excellent and effective communication, and interpersonal skills, with the ability to inspire, motivate and mentor a diverse team.

• Expertise in building and maintaining strong relationships with internal and external stakeholders.

• Proven track record of effective decision making. Consistently and effectively has made trade-off decisions that balance priorities and goals in a fashion that benefits both efficacy and business.

• Proven ability to manage budgets a