Principal Scientist/Senior Principal Scientist

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Our Drug Product Development team is committed to CMC design, development, and commercialization of innovative drug products to improve patient lives. We leverage the best people, collaboration, and cutting-edge innovation to achieve this commitment. BMS’s internal engine of innovation includes unrivaled industry leading expertise in CMC development of small molecules, protein biotherapeutics, protein degraders, and other therapeutic modalities. We collaborate closely with our colleagues in R&D and Commercial to design our drug products. Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope.

Position Summary:

This position will be part of Sterile Product Development within the Drug Product Development organization located in New Brunswick, NJ. We are seeking a collaborative, self-motivated, and results oriented scientist/engineer with a passion for problem-solving to extend and enhance patient lives, with a focus on formulation and process development. The successful candidate excels in a collaborative, cross-functional, matrix team environment to enable the development of new drug products for pharmaceutics, biologics, and emerging modalities such as, but not limited to, antibody-drug conjugates, gene therapy, oligonucleotides, and SiRNA nanoparticulate delivery. The scientist/engineer will design and execute studies to develop patient centric parenteral dosage forms and their manufacturing processes to enable clinical and commercial use.  

Responsibilities:

• Drive drug product development as a member/leader of multidisciplinary project teams in a matrix environment, striving towards objectives aligned with Drug Product Development goals.
• Proactively apply scientific or engineering expertise to develop solutions to complex technical, operational, and/or business problems which require ingenuity and creativity.
• Develop parenteral dosage forms for clinical and commercial use throughout various stages of development.
• Design and conduct experiments on new drug candidates and formulations to define biophysical and chemical properties using various analytical characterization tools.
• Conduct process development, optimization and scale-up studies; bring this knowledge to project teams to enable successful drug product technology transfer to clinical manufacturing and commercial sites.
• Generate data and knowledge for regulatory filings through planning and execution of experimental plans with minimal supervision, within project timelines.
• Integrate and interpret research data and present conclusions as appropriate at various project meetings.
• Issue periodic reports and ensure compliance to safety rules and regulations, experimental best practices, electronic laboratory notebook, and other expectations and trainings based on corporate and regulatory guidelines.
• Participate on appropriate portfolio and strategy initiative teams.
• Maintain awareness of advances in drug product development science and technologies to evaluate innovative opportunities to enhance productivity and efficiency of workflows.

Qualifications:

• Principal Scientist Level: Ph.D. with 5+ years of experience or MS with 6-9 years of experience with degree in Pharmaceutics, Biochemistry, Chemistry, Pharmaceutical Chemistry, Molecular Biology, Bioengineering, Chemical Engineering or related disciplines.
• Advanced knowledge and understanding of principles (scientific, engineering and quality by design principles, business processes) related to pharmaceutical drug product development of injectable dosage forms.
• Experience with process development (lyophilized or ready-to-use presentations) and scale-up of injectable dosage forms to clinical or commercial manufacturing s