Principal Scientist I, Precision Medicine Translational Research Immunology

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn. 

Job Description

We are seeking a highly motivated and creative Scientist with a scientific background in immunology or immuno-oncology to join Precision Medicine Translational Research Immunology Group as Principal Scientist at AbbVie.  The candidate will provide leadership in clinical biomarker strategy and assay development in inflammatory/autoimmune disease areas, including Dermatology, Gastroenterology, Rheumatology and Fibrosis for AbbVie’s drug development programs from late discovery to clinical trials.  The successful candidate will be part of a growing translational research group working with cross-disciplinary teams both internally and externally.  

Key Responsibilities: 

• Lead biomarker strategies through cross-functional teams in a matrix environment to identify gaps and develop fit-for-purpose clinical TE/PD biomarker, predictive and exploratory biomarker assays to support human dose projection and establish early signs of efficacy in clinical trials and patient selection strategies.
• Collaborate with Data Science team and Precision Medicine lead to analyze internal and external omics data, understand heterogeneity of diseases, identify disease endotypes, support disease strategy and generate patient selection and combination hypotheses for further testing with preclinical studies.
• Develop preclinical patient derived disease models, design studies with appropriate controls and endpoints to understand drug target mechanisms for PD biomarker development and evaluate biomarker hypotheses and combination strategies. 
• Serve as a subject matter expertise in analytical methodologies/technologies for translational research including single cell and spatial omics, proteomics, methylomics, metabolomics, genomics, NGS, MSD, ELISA, Lumi