Senior Director, Global Scientific Content

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Senior Director of Global Scientific Content is responsible for leading the development and execution of scientific content within Madrigal Medical Affairs. This role contributes to the Medical Affairs and Scientific Communication Plans, ensuring the globalization and alignment of content initiatives.

The Senior Director partners closely with Medical Affairs colleagues to deliver high-quality, impactful scientific content that support both internal stakeholders (e.g., Field Medical, Health Systems) and external stakeholders (e.g., healthcare professionals). These efforts enable effective scientific exchange and communication with impact. The position reports to the Vice President of Scientific Communications (or assigned delegate) and is a hybrid role (three days per week at Conshohocken, PA).

All incumbents are responsible for following applicable Division & Madrigal policies and procedures.

Key Responsibilities and Primary Activities: 

Approximately half (~40%) of the priorities and effort for this role is spent executing functional priorities and objectives, while the other half (~60%) focuses on providing direction, adapting priorities to achieve strategic objectives and leading the team.

• Strategic Planning and Alignment
  • Define and prioritize global scientific content needs of internal and external stakeholders, including Health Systems content as appropriate
  • Ensure scientific content planning is aligned with Madrigal Medical Affairs strategies and Scientific Communication platforms, as well as the training plans
  • Create and execute the global scientific content plan for the fiscal year, including alignment with the Medical Plan, detailed tactics, interdependencies, ownership, and budget
• Content Development
  • Oversee the creation, adaptation, and distribution of global content across multiple channels to deliver consistent and impactful information for scientific exchange
  • Support the development of comprehensive content strategies that leverage digital and omnichannel approaches to enhance engagement with healthcare professionals (HCPs) and internal stakeholders, ensuring alignment with scientific communication platform within compliance and practice standards
  • Ascertain scientific accuracy, stakeholder relevance, and appropriateness of the various formats utilized across all the scientific content materials
  • Champion unwavering commitment to scientific rigor and data-driven decision-making
• Alignment with Training
  • Ensure alignment with global scientific training program for field medical and other relevant stakeholders, ensuring best in class training on new content
  • Gather key insights and key learnings from the evaluation of the impact of training initiatives by analyzing metrics and feedback, ensuring insights are considered for scientific content
• Team Leadership & Development
  • Lead, inspire, and develop a high-performing global scientific content team, fostering an inclusive culture of scientific excellence, accountability, and collaboration 
  • Provide mentoring, coaching, and growth opportunities to ensure ongoing development of team members and future leaders 
  • Align all global content strategy and execution activities with organizational strategic objectives and tactical imperatives, serving as a key thought leader and advisor within Medical Affairs 
• Cross-functional Collaboration
  • Partner with internal cross-functional and regional teams to align on scientific content priorities
  •  Accountability for the coll