Senior Research Investigator, PBPK

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Translational Medicine & Clinical Pharmacology (TMCP) Department advances scientific discoveries into clinical therapies, by integrating translation biomarkers, clinical pharmacology, and mechanistic modeling approaches, to optimize drug discovery and development and personalized medicine through close collaboration within R&D. Quantitative Pharmacology and Data Analytics (QPDA) is responsible for the Clinical Pharmacology characterization for small and large molecule assets across all therapeutic areas beginning with the entry in humans through registration and after commercial launch. The responsibilities encompass conducting mechanistic model-based Population PK and exposure-response (ER) analysis to drive dose selection, utilizing quantitative system pharmacology (QSP) and physiologically based pharmacokinetic modeling (PBPK) in to characterize PK/PD, DDI liabilities, implications for special populations, understanding the effects of formulation changes, as well as informing other critical drug development questions to influence company decisions. Furthermore, QPDA is responsible for representing mechanistic modeling at health authority interactions and compiling technical documents that are critical for worldwide submissions.

Senior Research Investigator, PBPK

The scientist in this role will join an established Physiologically Based Pharmacokinetic (PBPK) modeling team with demonstrated and growing impact across the pipeline.  PBPK modeling has become an important component of drug discovery and development.  PBPK models are used to characterize the drug absorption, distribution, metabolism, and excretion (ADME) properties based on calibration to non-clinical and clinical data.  This enables extrapolation and generation of hypotheses to inform clinical development.  Additional applications include drug-drug interaction (DDI) risk assessment, PK and dose predictions in humans and special populations, prediction of target tissue concentrations, formulation optimization, and early differentiation between lead and backup molecules.  PBPK models are often extended to provide projections of target engagement, and pharmacodynamics have been incorporated.  Our QSP&PBPK team has established expertise, impact, tools, a strong intellectual environment, and capable colleagues.  The individual in this role will take on a variety of projects across therapeutics areas as well as preclinical and clinical development. 

An individual is being sought at the Senior Research Investigator level and the site location is Princeton, NJ working a hybrid work schedule.

 Responsibilities:

• Provide leadership to and collaboration with multidisciplinary project teams to develop and apply PBPK models
• Demonstrate high proficiency in the development and application of PBPK models to address drug discovery and development questions
• Partner with external groups to accelerate the internal PBPK efforts in key disease areas
• Independently provide expert support to project teams to design, execute and interpret clinical pharmacology studies
• Coordinate with QSP&PBPK methods group on new methodologies for innovative PBPK model development and application
• Network with stakeholders in non-clinical DMPK, biotransformation, and pharmaceutical development to identify and interpret experiments critical for model development and refinement
• Align PBPK model deliverables with clinical pharmacology, pre-clinical, and clinical development plans as appropriate
• Begin to learn how to align application area PBPK strategy with organizational priorities
• Contribute to the standards of practice within the department
• Participate and c