Sr. Director, Commercial Supply Chain

Structure Therapeutics develops life‐changing medicines for patients using advanced structure‐based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‐stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top-tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

 

Position Summary:

Reporting to the VP, Global Manufacturing & Supply Chain, the Sr. Director of Commercial Supply Chain will provide strategic and operational leadership for end-to-end supply chain planning across late phase clinical and commercial programs. This role is responsible for ensuring uninterrupted supply of small molecule drug substance, drug product and packaging & labeling through robust planning, inventory management, and cross-functional coordination.

The successful candidate will lead Sales & Operations Planning (S&OP) and Clinical Operations Planning (C&OP), support launch readiness, and establish scalable systems and processes to support a growing global supply network ensuring 100% supply reliability to patients.

 

Job Responsibilities:

Strategic Supply Chain Leadership & Planning

• Define and execute global supply chain strategies to support clinical development, commercialization, and lifecycle management.
• Lead end-to-end Sales & Operations Planning (S&OP) and Clinical Operations Planning (C&OP) processes.
• Ensure alignment of demand forecasts with manufacturing and supply capabilities.
• Provide strategic input into supply chain network design, long-term capacity planning, and budget development.

Demand Planning, Forecasting & Supply Balancing

• Collaborate with Clinical Operations, Commercial, and CMC teams to develop accurate demand forecasts.
• Lead demand and supply balancing activities across all supply chain echelons.
• Establish processes to continuously refine forecasts and improve planning accuracy.
• Ensure alignment of demand signals with production and procurement plans.

Inventory Management & Optimization

• Define and manage inventory strategies across the global network.
• Establish operational and strategic safety stock levels to mitigate supply risk.
• Monitor inventory performance, including turns, expiry risk, and working capital.
• Drive optimization of inventory levels to balance service, cost, and risk.

Launch Planning & Commercial Readiness

• Lead supply chain planning for product launches, including scenario planning and risk mitigation.
• Ensure readiness of supply chain systems, processes, and inventory to support successful launches.
• Partner with cross-functional teams to support regulatory milestones and market entry.

Network Planning & Risk Management

• Lead long-range supply chain network planning to support growth and commercialization.
• Identify and mitigate supply risks through scenario planning, redundancy strategies, and contingency planning.
• Develop and maintain risk management frameworks across the supply chain.
• Support business continuity planning and supply resilience initiatives.

Systems, Tools & Data Management

• Lead design, selection, and implementation of supply chain planning tools.
• Ensure effective master data management to support planning and execution.
• Support ERP system implementation and integration for new products and supply chains.
• Drive digital transformation and data-driven decision making in supply chain operations.

Logistics, Distribution & Storage

• Oversee storage, shipping, and distribution strategies for clinical and commercial products.
• Ensure compliance with requirements for controlled room temperature (CRT) and cold chain products.
• Coordinate logistics across global CDMOs, depots, and distribution partners.
• Optimize distribution networks to ensure timel