Senior Scientist Protein Science & Engineering Large Molecule Biologics

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Job Description 

Job Title: Advisor, Bioanalytical Research

Organization Overview: 

The Bioanalytical Research Group (BAR) at Lilly’s research facility in South San Francisco, CA is seeking a strong scientist skilled in protein mass spectrometry to deliver innovative ways in our evaluation of the ADME properties of therapeutic proteins and antibody-drug-conjugates (ADCs). 

The team works with Investigative ADME, Toxicology, Oncology, and Biotechnology Discovery Research to discover and characterize optimal ADC candidates to advance to clinical testing. 

Primary Responsibilities: 

• The development and application of QQQ and high-resolution LC/MS approaches to characterize the PK, biotransformation, and biodistribution of ADC drug candidates in pre-clinical animal models. 

• The application of mass spectrometry and wet biochemistry to answer questions related to target engagement and mechanism of action of ADCs. 

• Support Bio-Analysis sample preparation, experimental design, and mass-spec analysis of biological samples as well as data analysis/interpretation from in-vivo studies from triple-quad mass spectrometers (Sciex 7500). 

• Maintain a high level of productivity in a laboratory setting. This role is 100% on site in South San Francisco and is lab based, but will have opportunities to present the data to project teams. 

• Counsel the research activities of and mentoring junior laboratory staff in mass spectrometry, bioanalysis, and protein chemistry. 

• Serving as the Bioanalytical Project Lead for discovery projects requiring input from a highly qualified scientist on issues related to PK/PD,