Principal Scientist - Biotherapeutics Polyreactivity & Developability

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Challenging. Meaningful. Life-changing. Those aren��t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

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When you join BMS, you are joining a diverse, high-achieving team united by a common mission. 

The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents.  We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Principal Scientist Biotherapeutics Developability

Bristol Myers Squibb is seeking a highly motivated and innovative Senior Scientist with demonstrated expertise in antibody developability and characterization of monoclonal antibodies, bi/multispecifics, Fc-fusion proteins, and antibody-drug conjugates (ADCs) to join our Discovery Biotherapeutics team. Responsibilities will include a range of activities related to antibody and therapeutic protein developability characterization including but not limited to high-throughput plate-based screening for polyreactivity, analytical chromatographic methods for hydrophobicity, molecule integrity and pharmacokinetic prediction, and high throughput assays for manufacturability. This role will work in close collaboration with the protein engineering and characterization teams to test, design and optimize early to late-stage therapeutics to accelerate biotherapeutic discovery. The ideal candidate should also have knowledge/experience in protein chemistry, protein engineering, in silico modeling and prediction, and generation of large high-quality datasets to aid in generating training datasets for AI/ML guided therapeutic design.

Responsibilities:

• Develop and perform plate-based methodologies to address biotherapeutic polyreactivity for a range of modalities including antibodies, bi-/multi-specific antibodies, Fc-fusion, VHH, ADCs, etc.
• Serve as the lead and point of contact on antibody developability, managing requests, performing diverse assays, analyzing, communicating results, and cataloging of all data in databases.
• Execute on early to late-stage characterization for the developability of biotherapeutics including biophysical and bioanalytical methods involving plate-based assays, chromatographic methods, stability and aggregation propensities, structural properties, etc. with the goal of feeding training sets for ML and utilizing the output for improved therapeutic design.
• Demonstrate significant expertise in biophysical and bioanalytical characterization of large molecules to address hydrophobicity, polyreactivity, polyspecificity, self/cross‑interaction, colloidal and conformational stability, aggregation propensity, chemical stability, half-life (PK) predictors, and ADC toxicology predictors.
• Proactively identify liabilities for antibody developability, manufacturability or pharmacokinetics and work with protein engineering teams to guide design and optimization using sequence and computational prediction tools.
• Serve as the point of contact on antibody polyspecificity, managing requests and communicating results.
• Collaborate with multiple project teams in all disease areas to advise on key metrics of antibody