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Job Description

About the role:

At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on four therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.

Design and implement in vitro screening to identify lead therapeutic biologics and address mechanisms-of-action. Perform complex cell-based functional experiments independently. Act as a subject matter expert (SME) for drug discovery in the GI & Inflammation/Neuroscience (GI^2/NS) therapeutic areas.

How you will contribute:

• Provide broad assay development support for early stage drug discovery projects in GI & Inflammation, and Neuroscience (GI^2 and NS) therapeutic areas

• Design, troubleshoot, validate, and execute a variety of assays to characterize developability and mechanism of action of novel biologics

• Collaborate with automation engineers to leverage automated/semi-automated execution of cell based assays

• Analyze and interpret data, interface with project teams to meet timelines and milestones, and present findings

• Spend ~85% of time in laboratory to maintain and implement cell based assay platform and perform experiments

DIMENSIONS AND ASPECTS

• Experienced in the design, development and implementation of in vitro cell based functional assays to study target-specific drug effects

• Knowledge and experienced in cell biology and antibody characterization

• Experience with cell culture and functional assays including: on-cell binding, reporter assays, PSR, MSD, flow cytometry, cell adhesion, cell migration, and imaging

• Skilled in data analysis, interpretation, and data reporting

• Experience in troubleshooting, assay optimization and data quality control is a plus

• Experience with functional characterization of CART is a plus

• Working knowledge of disease areas in GI/Inflammatory, Neuroscience and/or immunology is a plus

Leadership

• Excellent written and verbal communication skills, along with the ability to work with cross-functional project teams

• Ability to work independently and self-driven in managing and accomplishing daily tasks

Decision-making and Autonomy

• Design and iterate complex protocols for cell-based functional assay development

• Independently manages workflow based on high-level direction

• Troubleshoots complex problems and participates in innovation and/or optimization of established processes to ensure data relevance and quality 

• Analyze and summarize results to impact data-driven decision making

Interaction

• Ability to work both independently and in a matrix-environment

• Works well under minimal supervision

• Collaborative and team-oriented

• Engage within and outside of the department to understand cross-functional priorities

Innovation

• Participates in new technology assessment under supervision

Minimum Requirements/Qualifications:

• MS with 2+ years experience, or

• BS with 3+ years experience

More about us:

At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals