Sr. Scientist, Purification

Job Description

Our Research Laboratories is focused on the discovery and development of world-changing therapeutics. Our state-of-the-art facility drives all aspects of drug discovery, development, manufacture, and commercialization of small molecules, biologics, and vaccines. Our multi-disciplinary research site offers cutting edge technology and resources to explore the most promising science combined with our company’s world-class Research & Development expertise for inventing medicines. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our Research Laboratories, you will have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

We are seeking a highly motivated Senior Purification Scientist who will work in a highly collaborative environment providing purification support to a multi-modality Discovery Chemistry portfolio in the High Throughput Purification group. The candidate will demonstrate scientific excellence, analytical chemistry knowledge, and the ability to use state-of-the-art preparative instruments for high-quality and high-efficiency purifications. Additionally, the individual should be proficient in data analysis using instrument software and automation technology to streamline synthesis-to-assay workflows.

Responsibilities are as follows:

• Use a wide range of established techniques, HPLC, SFC and Mass Spectrometry to support Discovery Chemistry portfolio.
• Setup, implement and maintain of lab-deployed analytical and preparative instrument, specifically, Waters or Agilent mass-directed preparative system.
• Develop novel purification capabilities and implement automation and data integration to optimize end-to-end purification workflow
• Interact closely with chemists and other purification groups across our Research and Development Division to share best practices and develop new capabilities.
• Collaborate with IT professionals to integrate instrumentation with LIMS system
• Program, integrate, and troubleshoot liquid handling, UPLC, LC/MS equipment from vendors including Waters, Agilent, Tecan.
• Knowledge of informatics such as Spotfire, VB, Pipeline pilot, and basic windows programs.

Qualifications:

• Bachelor’s degree in Chemistry, Engineering, Computer Science, Life Sciences or equivalent and  5 years of technical expertise in purification science, knowledge of analytical chemistry, strong organizational and communication skills, an ability to adapt to a fast-paced team environment, and experience with state-of-the-art purification technologies and automation systems.
• OR - Master’s degree and 3 years of experience

Required Experience: 

• Demonstrate working knowledge of analytical chemistry and ability to use a wide range of state-of-art preparative instrument to deliver the high quality, high efficiency purifications.
• Proficient in data analysis using instrument software, such as Masslynx, ChemStation, or Virscidian, and able to use automation technology to streamline the end-to-end synthesis to assay workflow.
• Ability to think strategically, highly organized with strong attention to detail.
• Apply scientific knowledge to assist with scientific decision-making and application of appropriate technologies.
• Excellent communication and interpersonal skills and the ability to work in a fast-paced team
• Strong instrument troubleshooting and routing maintenance abilities.
• Must be able to prioritize resources to deliver required level of output for highest priority projects.

• Self-starter with ability to work independently and multi-tasking.

Preferred:

• Experience working in pharmaceutical or biotech company.
• Experience working in a synthetic and/or analytical chemistry laboratory.
• Experience with Waters or Agilent analytical and preparative instrument, liquid handling systems – (HighResBio, Beckman,Tecan).
• Proficient in data analysis using Masslynx, ChemStation, Virscidian, and other data analysis software
• Experience with implementing and integrating large scale and small-scale automation with LIMS, eg. Empower, GBG, Cellario, Momentum.
• SQL/Oracle programming
• Microsoft programming languages (VB, C++, python, or equivalent)

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