Principal Scientist/In Vivo Lead--Oncology
PfizerAbout the role
POSITION SUMMARY
You will participate in pre-clinical drug discovery and development projects with a focus on ADC Biology and Cancer Immunology. You will be responsible for working with project teams to design, plan and execute an in vivo strategy to ensure efficient and effective decision-making. You will also be a key contributor to the In Vivo Committee, responsible for presenting study plans and obtaining peer input for protocol finalization and approval to meet research project objectives. You will directly supervise laboratory staff that make up an in vivo team responsible for study performance and data analysis, in addition to playing a role in the In Vivo Pharmacology department strategy. You will provide technical and scientific expertise in in vivo pharmacology across the Oncology Research Unit (ORU) to enable target identification, validation, prioritization and efficient drug discovery.
POSITION RESPONSIBILITIES
Collaborate across project teams to establish scientific in vivo strategy and study plans for drug discovery projects.
Serve as the in vivo pharmacology lead for several drug discovery projects. Ensure that projects have all critical in vivo data to enable project stage dependent decisions.
Work within multi-functional teams to support target identification, validation, drug discovery and combination therapy.
Work across in vivo teams in a highly collaborative manner, sharing expertise and resources to meet study needs across In Vivo Pharmacology.
Design and conduct in vivo studies to evaluate and establish efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.
Supervise and guide a small team of scientists
Develop and characterize new in vivo mouse models, including cell-line derived xenografts, syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies.
Ensure team members comply with all regulatory requirements and internal policies.
Facilitate and lead the development and execution of ancillary in vitro assays necessary to maximize value of the contribution by the in vivo team, if necessary.
Interpretation, presentation and documentation of experiments as well as preparation of reports. Written and verbal presentation of results within a multidisciplinary team environment.
Contribute to relevant in vivo sections of study reports and regulatory documents e.g., IND filings.
Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.
QUALIFICATIONS
Must-Have
Ph.D. in Cancer Biology, Immunology, Biochemistry, Genetics or a related discipline
Minimum 5 years industry experience including technical and scientific experience in drug discovery and preclinical development.
Experience in collaborative research in Oncology drug discovery programs.
Experience with animal models of human cancers
Hands on in vivo (e.g., IV, PO dosing, blood/tissue collection) and ex vivo skills (e.g., flow cytometry, western blot, ELISA).
Experience supervising a small team of Scientists
Excellent written and oral communication and presentation skills
Proficiency with all common office and scientific software
Preferred
Strong track record of publications or evidence of equivalent achievements in industry
Experience with GEMM and humanized models
PHYSICAL/MENTAL REQUIREMENTS
Lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS
Must be willing and able to work after hours as needed to ensure study integrity
Relocation support available
Work Location Assignment: On premise
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