Principal Technical Program Manager

About the Role

We are seeking a highly experienced Principal Technical Program Manager to lead large-scale, cross-functional programs across Life Science Group (LSG) and Clinical Diagnostics Group (CDG) initiatives. This role will drive program execution, R&D alignment, AI/ML innovation, platform modernization, and regulatory-compliant product delivery within a highly regulated environment.

Key Responsibilities

Program & R&D Leadership

• Lead end-to-end delivery of multi-team programs across LSG and CDG product portfolios.
• Serve as the primary technical program interface between R&D and engineering teams.
• Translate research and laboratory innovations into scalable platform development roadmaps.
• Drive AI/ML initiatives, including computer vision, predictive diagnostics, and LLM-assisted documentation.
• Facilitate cross-functional alignment and provide executive-level program updates and recommendations.
• Present risk mitigation strategies and resolution plans to senior leadership and executive stakeholders.

Architecture & Delivery Excellence

• Participate in architecture reviews and guide build-versus-buy decisions.
• Establish and maintain SAFe/hybrid-agile program management practices.
• Define and govern program milestones, OKRs, dependencies, and risk management processes.
• Drive CI/CD and DevSecOps adoption for embedded software and instrument development teams.
• Develop executive-ready reporting and mentor program managers and project leads.

Basic Qualifications

• Bachelor's degree in Computer Science, Biomedical Engineering, Biochemistry, Engineering, or a related discipline.
• 12+ years of experience leading complex, cross-functional technical programs with budgets exceeding $5M.
• Strong experience managing programs within Life Sciences, Diagnostics, Medical Devices, or regulated healthcare environments.
• Experience with SAFe, LeSS, Agile-at-Scale methodologies, Program Increment planning, and Agile Release Train facilitation.
• Deep understanding of IVD product development lifecycle and regulatory frameworks, including:
  • 21 CFR Part 11
  • IEC 62304
  • ISO 13485
• Experience supporting molecular biology workflows such as PCR, ddPCR, electrophoresis, or flow cytometry.
• Strong background in embedded systems, instrument software, firmware, and hardware development programs.
• Knowledge of cloud-native platforms (AWS and/or Azure), APIs, microservices, CI/CD, and DevSecOps practices.
• Experience managing AI/ML program delivery, model governance, and enterprise AI initiatives.
• Strong executive communication and stakeholder management skills.

Preferred Qualifications

• Master's degree or PhD in Life Sciences, Biomedical Engineering, Computer Science, or a related field.
• PgMP, PMP, SAFe SPC, or equivalent program management certification.
• Experience with laboratory environments, including CLIA, CAP, QC systems, and proficiency testing.
• Familiarity with New Product Introduction (NPI) governance processes.
• Experience with platform engineering, Infrastructure as Code (IaC), and developer platform strategies.
• Working knowledge of embedded software development using C/C++ and Python.
• Experience with enterprise AI platforms such as Claude, Azure OpenAI, or similar technologies.
• Familiarity with enterprise systems including SAP, Salesforce, ServiceNow, Jira, and Confluence.
• Proven ability to mentor TPMs and influence cross-functional teams in global matrix organizations.