Advisor/Senior Advisor, Purification Development - Bioconjugates

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Position Summary:

The Bioproduct Research and Development organization strives to deliver creative medicines to patients through the development and commercialization of insulins, monoclonal antibodies, bioconjugates, novel therapeutic proteins, peptides, oligonucleotide therapies and gene therapy systems. This organization is a multidisciplinary group that works collaboratively with our discovery and manufacturing colleagues. Located in Indianapolis, scientists have full access to our scientific excellence and engineering capabilities.

Do you enjoy downstream drug substance processes including purifying and filtering monoclonal antibodies, recombinant proteins, viral vectors, bioconjugates (such as antibody-oligonucleotide conjugates, ADCs, and PEGylated proteins), and peptides? Do you have experience with process development and tech transfer? Are you skilled in the analytical techniques used to characterize bioproducts? If so, then a role as a Purification Development Scientist is waiting for you.

This role requires a strong scientific foundation, effective interaction and communication of technical information with, but not limited to, Safety, Environmental and Quality Team members, Purification Development colleagues, CMC Team members, Discovery team members, Analytical Services, Tech Service/Manufacturing Science representatives, Operations, Engineering, Regulatory and Maintenance personnel.

Especially important, in this role, is that you adhere to all safety and environmental guidelines and promote a proactive safety culture and environmental compliance in all areas.

Responsibilities:

• As a scientist in the Purification Development group, you will:

• Identify and develop new purification technologies

• Design optimized downstream drug substance processes for new biologic candidates with particular focus on complex bioconjugates.

• Maintain accurate records and interpret data to provide detailed information and analysis on the execution of experiments.

• Employ strategic thinking to overcome technical hurdles and oversee process and technical transfer to GMP manufacturing facilities, as they make their way from discovery to the clinic.

• Write technical reports, tech transfer documents and give presentations to summarize development activities.

• Have flexibility to accept new projects and challenges.

• Troubleshoot issues as they occur and identify trends and opportunities to reduce process variability.

Basic Requirements:

• PhD in Chemical Engineering or related degree focused on biological separation sciences OR

• MS in Chemistry, Chemical Engineering, or related degree with at least 5 years relevant experience in leading protein purification/process development OR

• BS in Chemistry, Chemical Engineering, or related degree with at least 8 years relevant experience in leading protein purification/process development

• Hands-on experience with bioconjugate purification

Additional Preferences:

• Ability to exhibit a high level of attention to detail, a quality-minded approach to experimental design and record keeping.

• Effective oral and written communication skills.

• Strong laboratory skills

• Experience developing, optimizing, scaling, and tech transferring conjugation reactions for mAbs or other proteins (e.g., PEGylation, ADCs, antibody-oligonucleotide conjugates)

• Experie