Senior Scientist, Chemistry

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

RayzeBio, a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA. The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals.

The Sr. Scientist will design and synthesize novel chemical constructs as potential new RPT therapies for cancer treatments. The Sr. Scientist will be a highly motivated and technically skilled synthetic organic, peptide or medicinal chemist with excellent interpersonal and communication skills.  The role will offer an opportunity to work as functional lead on multiple projects ranging from target selection through candidate nomination stages and can be expected to lead early-stage projects in an interdisciplinary setting. The role is highly technical and will need a person who enjoys leading from the bench with high productivity and data analysis skills and a comfort level in working under tight timelines.

Key Responsibilities:

• Design and synthesize novel peptide/small molecule compounds in support of SAR campaigns for pipeline projects.

• Contribute towards developing SAR on assigned projects, design and synthesize key target molecules to assess chemical/biological hypothesis.

• Independently plan and execute organic synthesis routes for complex molecules. Utilize modern purification and analytical tools to support synthesis and characterization of target compounds.

• Work in close collaboration with interdisciplinary team members to provide needed chemistry support to guide programs through lead identification/optimization phases.

• Work closely with chemists, DMPK, imaging and in vitro/vivo teams to ensure that target compounds are generated in a timely manner to support the screening funnel.

• Contribute experimental efforts in support of target selection and initiation of new TRP projects.

• Keep abreast of the literature in the field of RPTs, identify novel concepts and ideas to help advance the state of art in RPT field.

• Contribute towards IP filings and drafting of publications, presentations.

• Routinely present research findings, project updates in interdisciplinary team settings.

• Adhere rigorously to safety guidelines, regulatory standards and company policies and ensure a safe working environment.

• Identify external partners, KOLs, outside expertise that will help advance the pipeline.

• Supervise the work of junior scientists and ensure experimental rigor and high quality.

Education & Experience:

• PhD in synthetic organic, peptide or medicinal chemistry with 4+ years of post-PhD/postdoc experience or BS with 15+ years experience in Pharmaceutical/biotech R&D environments demonstrating successful accomplishments and productivity.

• Experience in working on targeted cancer therapy modalities such as RPTs, ADCs, PDCs is highly desirable. 

Skills & Qualifications:

• Well versed in modern synthetic organic/peptide/med chem principles and demonstrated track record of high productivity and achievements in the lab.

• High scientific curiosity and a learning mindset coupled with strong technical problem-solving skills and strong unde