Senior Scientist, In-Vivo Studies

Senior Scientist, In-Vivo Studies

Waltham, MA

Are you an innovative and highly motivated Senior Scientist with an extensive background implementing in vivo studies? AstraZeneca is seeking a key member to join our discovery team in Waltham, MA. You will be driving projects through the drug discovery process, using your expertise with in vivo model development and execution to establish systems that deliver datasets with direct impact on discovery efforts. Be empowered to act fast on smart risks and keep ahead in the fast-paced Oncology field!

Accountabilities

As a Senior Scientist, you will develop, conduct, and analyze in vivo experiments to assess the function of our candidate drugs. You will support cross-functional teams and work collaboratively to ensure the timely generation and dissemination of critical program data. You will also review emerging literature and internal data to help identify new potential targets and contribute to target validation activities. Additionally, you will serve as the liaison and lead for in vivo studies conducted with external colleagues and vendors, ensuring timely execution of robust data streams to support discovery efforts.

Essential Skills/Experience:

• A PhD in a relevant field with 0-3 years’ extensive in vivo model use or MS in a relevant field with 3-5 years’ experience in mouse model development and execution or BSc with at least 5 years’ experience in mouse model development and execution.
• A demonstrated ability to lead external in vivo studies through collaborations and CROs is essential.
• Strong background ex vivo analysis of mouse models, including techniques such as flow cytometry, histology, and molecular assessments (qRT-PCR, RNA/ChIPseq, etc).
• Ability to independently design and execute research plans for one or more programs, and to review, analyse, and interpret experimental results rapidly.
• Ability to draft, execute and record protocols and experiments in a timely manner and maintain an excellent laboratory notebook.
• Job complexity is high and requires the ability to work with high degree of independence as well of a sense of urgency.
• Proven track record of success in your research and experience preparing written scientific reports and oral presentations.

Desirable Skills/Experience:

• Strong interpersonal, influencing, negotiating and collaboration skills together with evidence of having used these to support problem solving and delivery in a team-oriented, collaborative environment.

At AstraZeneca, we are on a mission to eliminate cancer as a cause of death. We are a science-based, leading Oncology enterprise united in our vision. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. We foster a mindset of courage, where everyone is empowered to step up, innovate and work at pace. We lead through true collaboration, building collective wisdom by giving everyone a chance to input. It's science with an impact-making a difference for patients and people around the world.

About the Waltham Site

Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park BioHub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world’s most vibrant research centers.

Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams and the greater research community.

As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: