Scientist / Senior Scientist, Bioanalysis - Ligand Binding Assays

Who We Are:

At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs.

What We Do:

Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie)

About the Role:

We are seeking a highly motivated Scientist or Senior Scientist to join the Bioanalysis group with a strong preclinical focus, supporting early-stage biologics drug development programs. The primary responsibility of this role is ligand binding assay (LBA) development and bioanalysis for preclinical pharmacokinetic (PK) studies in rodents and non-human primates, primarily under non-regulated conditions. The position may also support regulated GLP toxicology studies and involve interaction with external CRO partners for method transfer and study execution. Experience with ADA assay development is desirable and would be considered an add-on to the primary PK-focused responsibilities.

_

Your Contributions (include, but are not limited to):

• Develop, optimize, and qualify ligand binding assays (e.g., ELISA, MSD/ECL, Gyrolab) to support preclinical non-regulated PK studies of antibodies, bispecifics, and fusion proteins in rodents and monkeys

• Perform hands-on bioanalysis of preclinical samples and ensure data quality, integrity, and scientific rigor

• Author and review bioanalytical protocols, assay qualification/validation reports, and preclinical study reports

• Analyze, interpret, and clearly communicate PK bioanalytical data to project and DMPK teams

• Collaborate closely with DMPK, toxicology, and pharmacology groups to support study design and data interpretation

• Interact with external CROs, including:

  • Supporting assay and method transfer

  • Providing technical oversight during outsourced studies

  • Reviewing CRO data, reports, and study documentation

• Troubleshoot assay issues and continuously improve assay performance and workflows

• ADA assay development and support (screening/confirmatory/titer) may be involved on selected programs and is considered a desirable add-on to the primary PK role

• At the Senior Scientist level: provide technical leadership, mentor junior scientists, and contribute to preclinical bioanalytical