Technical Research Assistant II, RNA Therapeutics

Site: Mass General Brigham Incorporated

 

Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

 

 

Job Summary

GENERAL SUMMARY / OVERVIEW:

The Gene and Cell Therapy Institute (GCTI) is a newly created system-wide Institute under Mass General Brigham. The Institute will foster a world-class gene and cell therapy program that will leverage ongoing, groundbreaking scientific research efforts across the MGB system. The mission of GCTI is to bring together the community of MGB investigators which can utilize gene and cell therapy platforms to achieve their scientific and clinical goals and improve the health of patients. The Institute will differentiate itself by harnessing the exceptional strengths of clinician scientists, the large and unique patient population, and major discoveries throughout the hospital system to propel MGB as the leader in Gene & Cell therapies.

We are seeking a motivated and skilled Technician to join our RNA Therapeutics team and participate in the development of novel RNA-based medicines and technologies. With guidance from senior scientific staff, the candidate who fills this role will develop RNA synthesis, purification, and analytical methods, and produce high quality RNA preparations for experimental applications and external parties. The successful candidate will have experience working in a research laboratory environment and be proficient in standard molecular biology techniques such as cloning, PCR, and electrophoresis. They would preferably have hands-on RNA synthesis experience, be detail-oriented and organized, and eager to work in a team environment.

 

Qualifications

PRINCIPAL DUTIES AND RESPONSIBILITIES:

• Perform a variety of routine procedures following established methodologies including in vitro transcription, silica purification, tangential flow filtration, HPLC, cloning, gel electrophoresis, plasmid outgrowth and purification
• Perform analytical techniques and record quality metrics, with a strong focus on accuracy and reproducibility in work
• With supervision, develop new processes for RNA synthesis and purification, and implement these processes on automation platforms
• Operate laboratory equipment, instruments and robotics to perform repetitive laboratory techniques; learn how to use new instruments
• Use universal safety precautions and proper personal protective equipment to protect self and co-workers from biohazardous materials; complete requisite trainings as appropriate
• Coordinate lab staff training in biosafety, chemical hygiene, and emergency procedures. Serve as the liaison with Environmental Health & Safety (EH&S) and Biosafety Offices for inspections, compliance documentation, and hazard mitigation.
• Oversee and maintain accurate inventory of reagents and lab supplies. Coordinate ordering, shipping, receiving, and documentation of laboratory supplies and capital equipment.
• Participate in lab meetings and generate ideas for improving efficiency and productivity in the lab’s operations.
• Communicate effectively with the team, discuss progress, and share data with supervisors
• All other duties as assigned

 QUALIFICATIONS:

• Bachelor's degree in life sciences, biochemistry, or chemistry with at least 1-2 years of experience in a laboratory setting
• Good organizational skills, detail-oriented
• Reproducibility of work with accuracy
• Sound degree of computer literacy
• Ability to methodically record data
• Good interpersonal and communication skills
• Ability to demonstrate professionalism
• Dedication to excellence

 PREFERRED COMPETENCIES:

• Experience working with mRNA, circular RNA, or long-noncoding RNA
• Experience with in vitro transcription and purification processes
• Experience with liquid handling automation

 

Additional Job Details (if applicable)

Working Conditions

• This role is onsite 5x/week

 

Remote Type

Onsite

 

Work Location

65 Landsdowne Street

 

Scheduled Weekly Hours

40

 

Employee Type

Regular

 

Work Shift

Day (United States of America)