Director/Senior Director, Translational Research and Clinical Biomarkers

Scorpion is a pioneering clinical-stage oncology company redefining the frontier of precision medicine to deliver optimized and transformational therapies for larger populations of patients with cancer. Scorpion has built a proprietary and fully integrated platform of the most advanced technologies across cancer biology, medicinal chemistry, and data sciences, with the goal of consistently and rapidly creating exquisitely selective small molecule compounds against an unprecedented spectrum of targets. Scorpion aims to leverage its platform to advance a broad pipeline of wholly owned, optimized compounds across three target categories: best-in-class molecules targeting validated oncogene targets; first-in-class molecules for previously undruggable targets; and first-in-class molecules for novel cancer targets.

We are seeking a highly experienced Director/Sr. Director with a strong background in developing and executing biomarker strategies for early clinical trials in oncology. In this role, you will work with Research and Development scientists to identify, develop and validate assays for pharmacodynamic, tumor response, and patient stratification biomarkers to support Scorpion’s precision oncology portfolio. The candidate will also contribute significantly to translational research activities to support oncology programs from the preclinical stage through clinical development.

Key Responsibilities

• Collaborate with cross-functional teams to identify relevant biomarkers for Discovery programs and design and execute biomarker-driven clinical trials
• Serve as an individual contributor and senior-level representative on Development teams to integrate, influence and deliver biomarker strategies to key programs from initial concept to execution, data delivery and results interpretation
• Manage and oversee contract research organizations, and other partners in the field of biomarker assay development
• Lead the development and validation of biomarker assays for clinical use, including proficiency testing, analytical validation, and clinical validation
• Establish and oversee quality control procedures related to biomarker analysis
• Analyze biomarker data and generate reports to support clinical decision-making
• Communicate biomarker data to internal stakeholders, external partners, and regulatory authorities
• Participate in the preparation of regulatory submissions related to biomarkers
• Collaborate with clinical operations teams to implement specific biomarker and exploratory sample collection and analyses in all relevant clinical studies in selected programs
• Design, oversee and manage internal and external research collaborations in areas of clinical technologies and translational research

Qualifications And Requirements

• Ph.D. or equivalent in a relevant scientific discipline with expertise in cancer biology/experimental therapeutics and 6+ years of experience in the pharmaceutical/biotechnology industry, with a focus on oncology biomarker and translational science
• Deep knowledge of biomarker discovery and development in clinical trials, including assay development, validation, and data analysis
• Demonstrated experience in leading clinical biomarker development for innovative early clinical development
• Demonstrated experience in leading cross-functional teams in the development and execution of biomarker strategies for clinical trials
• Experience developing and executing companion diagnostic strategy within oncology would be preferred
• Strong communication and presentation skills with the ability to generate scientific reports and presentations.
• Demonstrated ability to work in a fast-paced, dynamic environment.

 

Scorpion Therapeutics Inc. is an Equal Opportunity Employer who strives to create and maintain a diverse working environment. We do not discriminate for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Beginning October 13, 2021, Scorpion Therapeutics requires all new hires to be fully vaccinated against COVID-19. If you are unable to receive the vaccine due to a disability or serious medical condition, or because of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.