Senior Director, Digital Business Partnership - Pioneering Medicines

Flagship Pioneering is a biotechnology company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. We create about six new companies every year and incubate them through successive rounds of funding. 

Since launching in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value.  

Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.   

Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com. 

Position Summary:

Position Summary

The Senior Director, Digital Business Partnership – Pioneering Medicines (PM) serves as the strategic interface between PM leadership and Flagship’s Digital & IT teams. This role is accountable for aligning PM’s scientific, clinical, and operational objectives with FSP digital strategies. The Senior Director leads PM’s digital roadmap sponsorship, associated demand intake, and prioritization for digital initiatives originating from PM. They will collaborate closely with IT delivery leads in Research & Development Systems, Infrastructure & Operations, Enterprise Applications, Cybersecurity, Service Delivery, etc…), business analysts, and the Office of the CIO / PMO to ensure business needs are translated to Digital/IT initiatives, and delivered / supported accordingly.

The Senior Director is responsible for the strategic intake and prioritization of digital initiatives in alignment with business objectives and enterprise roadmaps.

Importantly, within IT, this role serves as a sponsor of the roadmap output, providing indirect management of project delivery and execution—with direct management residing within IT delivery teams, and project managers within the Office of the CIO. The Senior Director ensures that business intent is well-scoped, prioritized, and continuously aligned with PM Leadership as initiatives move from concept through execution, and into operational support.

Key Responsibilities

Strategic Alignment & Portfolio Ownership

• Act as the primary digital business partner to PM leadership across PM’s Operations, R&D, Clinical, TechOps, and Programs.
• Sponsor the PM digital portfolio, ensuring initiatives reflect strategic business priorities and are aligned to long-range plans.
• Translate business needs into strategic digital opportunity areas, identifying reusable solutions and enterprise-aligned capabilities.
• Represent PM’s digital objectives with IT leadership, and portfolio governance processes.
• Ensure early identification of digital dependencies across PM functions and communicate implications for platform or sequencing decisions.
• Collaborate with PM leadership to define and manage the Build budget (digital investments supporting strategic initiatives), ensuring alignment with the digital roadmap and prioritization model; partner with IT delivery teams on visibility into Run budget requirements to inform long-term planning.

Intake & Prioritization

• Own the intake and/or validation of business generated digital demand across PM’s functional domains.
• Coordinate prioritization discussions across business stakeholders and IT leaders to align investment, timing, and sequencing.
• Prepare business case inputs and ensure demand is supported by appropriate strategic context and readiness.
• Track intake through intake tools and dashboards in collaboration with the Office of the CIO.
• Ensure that PM’s functional teams understand intake processes and know how to engage with Digital Business Partnership.

Engagement with IT Delivery & Execution Teams

• Partner with IT delivery leaders in Research & Development Systems, Clinical Systems, Enterprise Apps, Infrastructure & Operations, and Cybersecurity to align delivery expectations and scope.
• Collaborate with IT delivery functions to ensure func