Principal Scientist, Pharmacokinetics

Job Description

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where we have codified its legacy for over a century. Our success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

We are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility, and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At our Research Labs in South San Francisco, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

The SSF Pharmacokinetics, Dynamics, Metabolism and Bioanalytics (PDMB) group is seeking an experienced Principal Scientist to contribute to our biologics, drug conjugates, and novel modality discovery and development pipeline. The ideal candidate will represent PDMB in project teams across multiple therapeutic areas, including Oncology, Cardiovascular metabolic disease, and Immunology. The candidate will develop a project team specific adaptable PDMB screening funnel and work closely with ADME, discovery bioanalytics and modeling partners to support lead identification/optimization, enable FIH translation, and compile non-clinical packages to support regulatory filing. The candidate will collaborate effectively with cross-functional partners in project teams to facilitate program progression through science-based decision making. The successful candidate must demonstrate the ability to work collaboratively in a fast-paced, dynamic environment and possess excellent scientific, interpersonal, and communication skills. Additionally, the candidate will influence DMPK strategy and new capability buildout.

Key Responsibilities:

• Project-team representative and subject matter expert for biologics drug discovery and development, including but not limited to drug conjugates, small molecule, multi-specific biologics, and novel modalities. Contribute to overall team strategy and lead the formation and execution of team-specific PDMB workflow.

• Design and execute in vitro and in vivo mechanistic and translational studies to evaluate the pharmacokinetic and metabolic properties of therapeutic proteins, such as drug conjugates and other modalities, to influence drug design, lead selection, and drive PK/PD translations. Be accountable for providing timely and high-quality PDMB data deliverables to teams.

• Author regulatory documents from FIH through registrational filing.

• Effectively partner across multidisciplinary interfaces and provide strategic DMPK guidance and support to drive new drug discovery and development.

• Contribute to departmental scientific initiatives and strategies; Foster a high-performance culture of innovation, collaboration, engagement, self-accountability, and inclusion.

• Stay abreast of external scientific advancements and contribute to the evaluation and implementation of new technologies and methodologies in DMPK for drug discovery.

Qualifications:

Education:

• Master's (with 12 years) or Ph.D. (with 8 years) in Pharmacokinetics, Pharmaceutical Sciences, Chemistry, Biochemistry, Biophysics, Biology, or related field with relevant industry experience listed below.

Required Experience and Skills:

• Demonstrated team-facing experience leading DMPK efforts in biologics, small molecule or conjugate discovery teams

• A proven track record of setting strategies and priorities, and managing resources as an independent project-team representative within a highly dynamic and collaborative environment.

• Proficiency in analyzing, interpreting, and providing context around data describing the DMPK and PKPD properties of therapeutic proteins; ability to extract preclinical PKPD/efficacy relationships and translate PKPD in humans.

• Demonstrated ability to effectively collaborate with cross-functional teams and communicate DMPK findings to inform decision-making in drug discovery and development.

• Strong problem-solving and leadership skills, highly motivated and self-driven with a keen interest in staying at the forefront of DMPK science and technology.