Senior Global Project Manager (Sponsor-Dedicated, Remote – US) - Phase 1

Senior Global Project Manager (Sponsor-Dedicated, Remote – US) - Phase 1

Syneos Health® is a leading fully integrated biopharmaceutical solutions organization built to accelerate customer success. We translate unique clinical, medical affairs and commercial insights into outcomes to address modern market realities.  

Our Clinical Development model brings the customer and the patient to the center of everything that we do. We are continuously looking for ways to simplify and streamline our work to not only make Syneos Health easier to work with, but to make us easier to work for.

Whether you join us in a Functional Service Provider partnership or a Full-Service environment, you’ll collaborate with passionate problem solvers, innovating as a team to help our customers achieve their goals. We are agile and driven to accelerate the delivery of therapies, because we are passionate to change lives.

Discover what our 29,000 employees, across 110 countries already know: 

WORK HERE MATTERS EVERYWHERE

Why Syneos Health

• We are passionate about developing our people, through career development and progression; supportive and engaged line management; technical and therapeutic area training; peer recognition and total rewards program.
• We are committed to our Total Self culture – where you can authentically be yourself. Our Total Self culture is what unites us globally, and we are dedicated to taking care of our people. 
• We are continuously building the company we all want to work for and our customers want to work with. Why? Because when we bring together diversity of thoughts, backgrounds, cultures, and perspectives – we’re able to create a place where everyone feels like they belong. 

Job Responsibilities

Senior Global Project Manager (Sponsor-Dedicated, Remote – US)

About the Role

The Clinical Trial Leader (CTL), is a Senior Project Manager level role and serves as a key member of the sponsor’s Clinical Delivery Team, providing leadership, direction, and accountability across the full lifecycle of Phase II and III global clinical trials. This role ensures accurate planning, efficient execution, and delivery of trials that bring speed and value to participating subjects and sites.

Operating across multi-country, global studies, the CTL provides strategic and operational oversight to ensure trials meet their defined milestones and key performance indicators (KPIs). The successful candidate will demonstrate strong scientific and operational expertise, outstanding communication, and the ability to influence across complex matrix environments.

This is a sponsor-dedicated position supporting the experimental team worldwide, with therapeutic areas including Immunology. Candidates must have extensive Project Management experience in Phase I trials (additional TA experience is a plus), and a 4-year undergraduate degree.

What You Will Do:

Trial Preparation

• Lead planning and operational feasibility assessments to ensure realistic and achievable trial timelines.

• Oversee trial set-up and ensure team alignment across functions including Statistics, Data Management, Medical Writing, and Site Monitoring.

• Support country allocation and feasibility processes; provide input to optimize site selection and trial readiness.

• Develop and implement trial-level engagement, recruitment, and risk mitigation plans, integrating patient and site feedback to enhance trial design and participant experience.

• Coordinate outsourcing of vendor services, supporting vendor identification, selection, and scope-of-work development.

• Partner with cross-functional teams to ensure readiness across all trial processes — clinical quality, safety monitoring, investigational product management, budgeting, and site support.

• Facilitate and support responses to regulatory authorities, ethics committees, and other external stakeholders.

• Ensure all trial team members receive appropriate study-specific and standardized training.

Trial Conduct

• Maintain oversight of global clinical trial conduct to ensure compliance with Good Clinical Practice (GCP), internal SOPs, and all applicable regulatory requirements.

• Oversee patient recruitment progress, risk mitigation, and budget tracking to ensure efficient delivery.

• Manage amendments to study documentation and related retraining as needed.

• Ensure effective oversight of vendors and central labs, in collaboration with functional partners.

• Support ongoing communication and coordination across the clinical delivery network and stakeholders.