Senior Research Associate, Antibody Sciences

Description

Job Title: Senior Research Associate, Antibody Sciences

Company: Immunome, Inc.

Location: Bothell, WA

About Us: Immunome is a clinical-stage biotechnology company dedicated to developing first-in-class and best-in-class targeted cancer therapies. Our portfolio pursues each target with a modality appropriate to its biology, including immunotherapies, targeted effectors, radioligand therapies and antibody-drug conjugates (ADCs). We believe that pursuing underexplored targets with appropriate drug modalities leads to transformative therapies. Our proprietary memory B cell hybridoma technology allows for the rapid screening and functional characterization of novel antibodies and targets. 

Position Overview: The Senior Research Associate in Antibody Sciences will be central to advancing our drug development pipeline. You will generate antibodies and other proteins to be used within the team and by other research teams and characterize the biophysical properties of the proteins generated. You will play a crucial role for our ongoing programs and shape the development of our novel therapeutic technologies.

Key Responsibilities

Research Design and Execution:

· Design plasmids for the recombinant expression of antibodies and other proteins of interest.

· Perform molecular cloning to generate expression plasmids.

· Express antibodies and other proteins transiently in mammalian cell lines and maintain the cell lines for expression.

· Purify proteins using primarily affinity and size-exclusion chromatography coupled to FPLC systems.

· Characterize the binding kinetics of antibodies using BLI.

· Characterize the biophysical properties of antibodies using biochemical and biophysical techniques like SDS-PAGE, HPLC, and DLS. 

Data Analysis and Interpretation:

· Analyze and summarize experimental data from protein expression, binding, and stability assays.

· Interpret results and communicate implications to developing technologies.

Project Collaboration:

· Collaborate with colleagues from diverse scientific disciplines, including biology, chemistry, pharmacology, and translational medicine to achieve project goals.

· Organize data for ease of collaboration with other research teams. 

Documentation and Reporting:

· Maintain detailed and accurate electronic laboratory notebooks documenting experimental procedures, results, and conclusions.

· Prepare and present research findings to internal teams a contribute to project updates and strategic discussions.

Continuous Learning and Development:

· Stay informed about the latest advancements in techniques for producing and characterizing protein therapeutics. 

Proactively seek opportunities for professional development and contribute to the scientific growth of the research team.

Requirements

Education and Experience:

Bachelor’s degree or Master’s degree in molecular biology, biochemistry, biophysics, or related field.

Minimum of 8 years of experience (or 5+ years of experience with a Master’s degree) in preclinical drug development in the biotechnology or pharmaceutical industry.

Other Experience and Skills:

· Deep expertise in mammalian protein expression and purification using AKTA FPLC systems.

· Experience in molecular cloning and plasmid purification. 

· Experience in protein analytics, such as SDS-PAGE, HPLC, BLI, and DLS. 

· Experience managing or mentoring direct reports is a plus.

· Ability to maintain detailed and organized experimental logs. 

· Ability to understand and communicate complex scientific data.

· Ability to collaborate effectively in a team-oriented environment.

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creating an inclusive environment for all employees.

Salary Range

$111,000-$146,000