Vice President, Project Management - RayzeBio

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Background 

RayzeBio is a dynamic biotechnology company headquartered in San Diego, CA. Launched in late 2020 and recently acquired by Bristol Myers Squibb (BMS) as a wholly owned subsidiary, the company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. RayzeBio operates as a standalone entity within the BMS organization, maintaining its biotech culture with the opportunity to leverage the best-in-class oncology capabilities of BMS. RayzeBio is developing innovative drugs against targets of solid tumors. The lead asset, RYZ101, is in Phase 3 testing for patients with gastroenteropancreatic neuroendocrine tumors (GEP-NETs), as well as earlier stage testing for patients with small cell lung cancer (SCLC).  In addition, Rayzebio has a leading radiopharmaceuticals pipeline with novel assets targeting HCC, RCC and Prostate cancer amongst others.  Led by a successful and experienced entrepreneurial team, RayzeBio aims to be the global leader in radiopharmaceuticals. 

Summary

The Vice President of Project Management at RayzeBio serves as a strategic leader and thought partner, responsible for shaping and guiding a high‑performing project management organization that spans the full drug development continuum from discovery research through clinical development, manufacturing, regulatory approval, commercial launch, and lifecycle management. This role is pivotal in advancing RayzeBio’s pipeline by driving operational excellence, embedding project management discipline into decision‑making, and ensuring programs progress efficiently through critical milestones. The Vice President will coach and develop project management talent, foster a culture of collaboration and innovation, and align program execution with the company’s strategic goals while representing RayzeBio’s approach to project management excellence within the broader biotech industry.

Job Responsibilities

Leadership & Strategy

• Provide strategic direction and leadership for the project management organization, ensuring alignment with RayzeBio’s objectives and pipeline priorities.

• Lead the project management for the NDA filing of our first asset (Player and coach required)

• Build industry‑leading asset and portfolio management capability across drug development to drive pipeline execution.

• Influence asset and portfolio decisions by identifying interdependencies and downstream implications across research, clinical, regulatory, medical, and commercialization.

• Guide decision‑making in the context of building portfolio value versus solely progression of individual assets.

Team Management

• Lead, mentor, and develop a high‑performing project management organization across early and late drug development as a centralized capability.

• Drive portfolio excellence through standardized operating practices across therapeutic areas, fostering a culture of excellence and continuous improvement.

• Serve as process owner of asset progression across governance checkpoints from first‑in‑human through registration and submission.

• Mentor and guide talent development, including succession planning, performance management, and recognition.

• Enable cross‑TA talent development opportunities to build a pipeline of project management talent across RayzeBio and the broader BMS portfolio.

Portfolio Operations & Risk Management

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