Senior Research Scientist/Principal Research Scientist, Cell Line Team

Description

Company Overview

Immunome is a clinical-stage targeted oncology company committed to developing first- and best-in-class targeted therapies designed to improve outcomes for cancer patients. We are advancing an innovative portfolio of therapeutics, drawing on leadership that previously played key roles in the design, development, and commercialization of cutting-edge targeted cancer therapies, including antibody-drug conjugate therapies (ADCs.) In addition to a portfolio of discovery-stage ADCs, our pipeline includes AL102, a gamma secretase inhibitor which is currently in a Phase 3 trial for treatment of desmoid tumors, as well as IM-1021, a ROR1 ADC, and IM-3050, a FAP-targeted radioligand, both of which are the subject of INDs expected to be submitted in the first quarter of 2025.

Position Overview

The Scientist in the Cell Line Team within Antibody Sciences will play a key role in advancing our drug development pipeline. You will generate antibodies, other proteins, or stable cell lines for use within the team and by other research groups, and you will characterize the biophysical properties of the proteins produced. Your contributions will be essential to our ongoing programs and will shape the development of our novel therapeutic technologies.

Key Responsibilities

Research Design and Execution

• Transiently express antibodies and other proteins in mammalian cell lines and maintain these cell lines for expression.
• Familiarity with large-scale bioreactor systems (1 L to 25 L) or Wave-related systems for protein expression.
• Understand the principles of Master Cell Bank (MCB) and Working Cell Bank (WCB) creation for use in process development and cell line development.
• Execute technology transfer documents for partner site process development (PD) and GMP manufacturing.
• Systematically optimize culture conditions, such as transfection or stable cell line generation, by using multiple parameters through Design of Experiment (DOE) methodologies.

Data Analysis and Interpretation

• Analyze and summarize experimental data related to cell growth, viability, titer, medium preparation, and culture conditions.
• Interpret results and communicate their implications for technology development.
• Familiarity with LIMS (Laboratory Information Management System) for data management.

Project Collaboration

• Collaborate with colleagues from diverse scientific disciplines, including biology, chemistry, pharmacology, and translational medicine to achieve project goals.
• Organize data for ease of collaboration with other research teams. 

Documentation and Reporting

• Maintain detailed and accurate electronic laboratory notebooks documenting experimental procedures, results, and conclusions.
• Prepare and present research findings to internal teams to contribute to project updates and strategic discussions.

Continuous Learning and Development

• Stay informed about the latest advancements in techniques for producing and characterizing protein therapeutics. 
• Proactively seek opportunities for professional development and contribute to the scientific growth of the research team.

Qualifications

• Bachelor’s, Master’s, or Ph.D degree in molecular biology, biochemistry, biophysics, or related field.
• A minimum of 8 years of experience (or 6+ years with a Master's degree, or 3+ years with a doctoral degree) in preclinical drug development within the biotechnology or pharmaceutical industry.

Knowledge and Skills

• Experience in designs and executes experiments for one-time use system, such as Ambr 15, Ambr 250, or XDR 50, or Wave system.
• Experience with automation and miniaturization of cell culture systems to enable high throughput experimentation.
• Experience working in process development in a CRO/CDMO environment is a plus. Experience in CRO vendor management is also a plus.
• Leads/participates in cross-functional CMC teams and reviews relevant sections of regulatory submissions (e.g. IND, BLA, NDA, etc…).
• Experience in software including Benchling, Geneious, FlowJo and JMP et al.
• Ability to collaborate effectively in a team-oriented environment.
• The demonstrated ability to lead research associates and engineers through urgent situations by developing actionable goals and robust implementation plans is plus.

E/E/O

Immunome, Inc. is an equal opportunity employer. We celebrate diversity and are committed to creat