Senior Director, Head of Mechanistic Pharmacology

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Biological Research

Job Category:

People Leader

All Job Posting Locations:

US026 PA Spring House - 1400 McKean Rd

Job Description:

Johnson & Johnson is recruiting for a Senior Director, Head of Mechanistic Pharmacology, located in Spring House, PA.

Our Discovery Technology and Molecular Pharmacology (DTMP) organization is looking for a Senior Director, Head of Mechanistic Pharmacology.  This Senior Scientific Director will report into our Vice President DTMP and lead a core function located at our two research sites including Spring House, PA and Lo Jolla, CA.  The incumbent will lead a state-of-the-art cellular screening capability with a special emphasis on the development and application of high throughput screening assays to support all TAs from portfolio entries to NME transition. This includes resource allocation and priority alignment.  In addition, their team will be responsible for mechanistic pharmacology assay development and platform execution to drive high throughput in-vitro mechanistic pharmacology data generation and address IVIVC needs using high throughput translational assay platform and scalable complex cellular models.  Receptor pharmacology and translational pharmacology will be the core expertise for this team. 

The incumbent will work closely with the DTMP senior leadership team to set the strategic direction for this core function, establish robust end-to-end processes and build high throughput cellular pharmacology assays across Discovery pipeline using technology innovation across multimodalities including small molecules, cell therapy, biologics, and RNA therapeutics. The incumbent will collaborate with the preclinical science and translational safety team to develop the translational pharmacology strategy and execute early safety risk assessment assays through technology innovation and lab automation to enhance therapeutic quality and incorporate the execution plans into our therapeutic transition packages.  In addition, the incumbent will regularly interact with the leaders across Therapeutic Discovery to provide appropriate insights and expert diligence on promising opportunities in the external innovation environment. The incumbent will lead the team to launch phenotypic screening strategy, drive our cellular technology/Biosignature platforms and deliver transition data to enable AIML model development and execution.

Major Duties & Responsibilities include but are not limited to:
•             Coordinate project needs and timeline and deliverables and resource distribution across portfolio and across sites

•             Address PPI and complex target capability and cellular target engagement

•             Drive important initiatives together with TD Modality leaders, TA leaders and DTMP leaders

•             Lead Innovation, drive functional efficiency to impact drug design, target ID, target engagement and tool molecule ID/hypothesis validation

•             Develop and execute partnerships with leaders across Janssen

Qualifications:

•             Masters in science is required. 

•             Leadership experience with at least 15+ years in both biochemical and cellular pharmacology industry with a strong record of individual and team-level contributions to the discovery and development of multiple novel small molecule clinical compounds and/or approved drugs.

•             Be an establish leader of leaders who is versed in managing Director level direct reports. 

•             Scientific expert with an outstanding record of high impact publications, oral presentations, and review articles.

•             Broad experience building high throughput cellular and pathway assay suites, and familiar with high content imaging technology with strong experiences in assessing cellular mode of action of molecules, and delivering comprehensive cellular pharmacology dat