Principal Scientist - Analytical Research and Development

OVERVIEW:

As a Principal Scientist, you will be at the center of our operations, and you’ll find that everything we do, every day, is in line with an unwavering commitment to quality. You will be recognized as a technical expert and a significant scientific contributor. With your deep knowledge of the discipline, you will regularly contribute to the therapeutic area level and can represent the department on multidisciplinary teams. 

With your deep knowledge of the discipline, you will work with internal and external partners around the world to manage and oversee GMP analytical readiness for novel  small molecule components for use in targeted therapeutics.  You will use strong communication skills to ensure technical and business line alignment across a variety of stakeholders within multidisciplinary teams.  It is your scientific diligence, knowledge, and focus on execution that will help in making Pfizer ready to achieve new milestones and help patients across the globe.  You will play a lead role in establishing an outsourcing culture and mindset within ARD.   
 
ROLE SUMMARY:
As a member of the Pharmaceutical Sciences Analytical Research and Development team, you will collaborate with project teams, development analysts, GMP analysts and external vendors to deliver multiple units of analytical work in parallel.   You will manage analytical testing through successful, timely delivery for internal project teams in support of small molecule drug development. You will apply your expertise in separations and chromatography as well as other analytical methodologies to enable drug development utilizing external resources.  

The candidate will be responsible for independently delivering technical work packages in support of drug development during all clinical phases.  Work will be predominantly focused on analytical development activities including validating and transferring analytical methods, developing, and executing general testing protocols aligned with ARD development workflows, critically evaluating vendor generated data and compiling summaries as required. 

The role requires collaboration with ARD colleagues to identify appropriate analytical approaches, ensuring vendors clearly understand Pfizer's needs, managing technical risks, and developing appropriate contingencies across a dynamic portfolio. This role also requires direct interaction with outsourcing colleagues in partner groups and therefore requires knowledge of API and DP development workflows. 

The candidate will manage differences in analytical instrumentation and operating procedures between the vendors and Pfizer, ensuring minimal technical impact on the work packages and data being delivered. The candidate will capture relevant feedback and facilitate the evolution of best practices and process improvements with the vendor.  

BASIC QUALIFICATIONS:

• Ph.D. in Analytical Chemistry or related field with 4+ years of R&D experience OR Masters in Analytical Chemistry or relevant industry experience with 9+ years of R&D experience, OR B.S. with 12+ years of relevant industry experience and analytical development experience. 

• Significant hands-on experience of the development and application of common analytical methods to support the progression of drug candidate development workflows. 

• Good Knowledge of the development workflows used by ARD’s key partners within PSSM.  

• Demonstrated ability to manage parallel projects, prioritize activities in a dynamic environment, meet timelines, and interact with multidisciplinary teams and stakeholders. 

• A breadth of diverse leadership experiences and the ability to lead change and work in new paradigms. 

• Attention to detail, strong organizational skills, and effective interpersonal and communication skills are required. 

• Demonstrated oral and written communication skills, including visualization of data, presentations, and authoring technical articles 

• Demonstrated ability to meet timelines and interact with multi-disciplinary teams.

• Demonstrated ability to learn new techniques and solve complex analytical problems.