Senior Associate Scientist - Lead Discovery and Optimization

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

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The Lead Discovery and Optimization Group within Therapeutic Discovery Sciences in San Diego focuses on delivering novel therapeutics for disease intervention by engaging E3 ubiquitin ligases for targeted protein degradation. We seek a highly driven senior associate scientist to help identify and characterize drug candidates for the treatment of human diseases. The successful candidate will work collaboratively in a multi-disciplinary environment to carry out cell-based and molecular assays in support of small molecule discovery for pre-clinical development.

Responsibilities will include but are not limited to the following:

• Design and implementation of high-throughput cell-based reporter assays to characterize drug candidates

• Establish stable cell lines via lentiviral transduction and maintain mammalian cell lines

• Conduct routine molecular and cellular experiments including DNA/RNA/protein extraction, immunoblot analysis, and immunoprecipitation

• Utilize Python, R, or similar programming languages to analyze, interpret, visualize, and communicate complex scientific data, applying advanced analytical techniques to generate actionable insights and support data-driven decision-making

• Assist senior researchers in executing, conducting analyses, and reporting results of experiments

• Familiarity with literature and internal best practices to identify opportunities to improve productivity and quality of work

• Analyze, troubleshoot, and recommend corrective actions for routine problems

• Maintain an accurate, comprehensive, and current laboratory notebook

• Write protocols, procedures, and technical reports

• Communicate results via written reports and oral presentations

Basic Qualifications:

• Bachelor’s Degree with 5+ years of academic and / or industry experience

Or

• Master’s Degree with 3+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences with no experience necessary

Preferred Qualifications:

• Expertise in mammalian cell culture, plate-based cellular assays, immunoblotting, lentiviral infection, cellular transfection, and basic molecular biology techniques

• Experience with medium and high-throughput screening is highly preferred

• Experience with targeted protein degradation assay is a plus

• Familiarity with automation instruments and multi-mode plate readers

• Demonstrated proficiency in Python, R, or similar programming languages, with the ability to apply advanced analytical techniques to interpret, visualize, and communicate meaningful results

• Outstanding problem-solving and organization skills.

• Effective team player and strong individual contributor

• Self-driven, flexible, pragmatic, and able to handle multiple tasks while delivering high quality data

• Effective communication skills, both verbal and written

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If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

San Diego - CA - US: $118,750 - $143,901

The starting compensation range(s) for this role are listed above for a ful