Senior Associate Scientist Analytical Characterization

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission. 

The Pharmaceutical Candidate Optimization organization at Bristol Myers Squibb is a dynamic, multi-disciplinary department that works to discover and optimize new drug candidates.  We work across all therapeutic areas and all modalities (small molecules, biotherapeutics, gene and cell therapies and other novel modalities), and engage with all other R&D functions to advance new assets in the BMS portfolio.  Our integrated, cross-functional teams apply deep expertise in drug metabolism, pharmacokinetics (DMPK), toxicology, pharmaceutics, and bioanalysis to identify and solve issues, discover high quality drug candidates, and enable their clinical development.

Here, you’ll get the chance to grow and thrive through opportunities that are uncommon in scale and scope. You’ll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

In Pharmaceutical Candidate Optimization (PCO), Discovery Pharmaceutics & Analytical Sciences (DPAS), you will have the ability to impact the lives of patients by working with multidisciplinary research teams to help discover novel, efficacious and safe therapeutic molecules.  BMS is looking for a research scientist to join our diverse analytical department in Drug Discovery to contribute to the primary structure characterization of different therapeutic modalities. This role is well-suited for a scientist possessing a strong background in protein mass spectrometry and data analysis to leverage novel technologies and methodologies for protein characterization of biotherapeutics, including monoclonal antibodies, bi/milti-specifics, ADC, Fc-fusion proteins, etc. This role will have responsibilities for defining and executing analytical strategies to expand existing capabilities and define the optimal analytical approaches necessary to support drug discovery programs.

Job Responsibilities:

The successful applicant will be primarily responsible for the following:

• Perform analytical studies on biotherapeutics to access chemical stability, glycosylation profile, fragmentation and aggregation during developability and platform formulation fit assessment utilizing chromatography and mass spectrometry in a fast-paced Discovery environment
• Execute peptide mass mapping, subunit, intact mass, glycosylation and post-translational modification analysis of proteins to support liability assessment of therapeutic modalities
• Operation and day to day maintenance of varies high end mass spectrometers Q-TOF (Waters), Orbitrap Exploris, Orbitrap Lumos (Thermo)
• Work in a team environment to evaluate and implement novel mass spec based techniques
• Represent the department on project teams and present data at internal department and / or other company meetings as well as external conferences.
• Maintain good laboratory practices and documentation (ELN)

Basic Qualifications:

• Bachelor's Degree with 4+ years of academic / industry experience
• or
• Master's Degree with 2+ years of academic / industry experience

Preferred Qualifications:

• Bachelor's Degree with 4+ years of academic / industry experience, with emphasis on protein characterization by mass spectrometry
• Experience with intact/subunit analysis, peptide mapping, glycosylation and PTM analysis of proteins using mass spectrometry
• Experience in protein and peptide chromatography and application of various modes of UPLC/HPLC (e.g, reversed-phase (RP), Size Exclusion Chromatography (SEC), Ion-Exchange (IEX), Hydrophobic interaction (HIC)