Postdoctoral Scholar, Multigene Expression Platforms

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com.

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Job Function:

Career Programs

Job Sub Function:

Post Doc – R&D Product Development

Job Category:

Career Program

All Job Posting Locations:

Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.
 

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.
 

Learn more at https://www.jnj.com/innovative-medicine   
 

We are searching for the best talent for a Postdoctoral Scholar, Multigene Expression Platforms to be located in Spring House, PA.
 

Purpose: This postdoctoral position focuses on advancing next‑generation CHO cell line engineering strategies to enable efficient and stable expression of complex multigene biologics, including bispecific and multispecific antibodies. The role will lead the design, construction, and evaluation of compact multigene expression architectures to address payload size and gene copy number limitations that constrain productivity in current manufacturing platforms. Through a combination of molecular biology, cell line development, and analytical characterization, the position will generate scalable expression solutions that improve integration efficiency, transcriptional balance, and antibody titers, directly supporting portfolio‑level biologics manufacturing innovation within Discovery, Product Development & Supply (DPDS).
 

You will be responsible for:

• Conducting research to advance biologics development platforms through innovative experimental design and data analysis.
   
• Applying molecular and cell‑based technologies to evaluate strategies that improve productivity and scalability in cell culture systems.
   
• Collaborating within a multidisciplinary research environment to generate insights that support next‑generation therapeutic development.
   
• Completing trainings, literature reviews, presentations, and symposia.
   

Qualifications/Requirements

Education:

• A PhD in Molecular Biology, Cell Biology, Microbiology, Biochemistry, or a closely related field relevant to biologics or cellular systems is required.
   

Experience and Skills:

Required:

• Advanced knowledge in molecular biology, cell biology or a related field, with demonstrated expertise in gene expression systems, vector design, and cell‑based biologics research is required.
   
• Advanced experimental design and data analysis skills, including the ability to independently plan, implement, and interpret complex biological data and trouble shoot is required.
   
• Extensive experience with molecular biology, mammalian cell culture systems, applying advanced laboratory techniques to evaluate expression, stability, and productivity in engineered cells is required.
   
• Strong proficiency in molecular and analytical methods used to design plasmid constructs for protein expression and to assess genetic integration, transcriptional output, and protein expression, with the ability to critically evaluate data quality and relevance is required.
   
• A strong research record, demonstrated through peer‑reviewed publications and/or scientific presentations is required.
   
• Advanced scientific communication skills, including clear documentation, data visua