Director, Business Strategy & Operations

Company Overview:

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a mission to deliver functional improvement for individuals, families and communities. Learn more at https://www.dyne-tx.com/, and follow us on X, LinkedIn and Facebook.

Role Summary:

The Director, Strategy & Business Operations is a strategic and operational partner to Dyne’s leadership, playing a central role in enabling effective Executive Committee (EC) and Board decision-making. This leader drives the end-to-end process for EC and Board submissions; synthesizes complex, cross-functional insights into decision-ready narratives; and leads high-priority, cross-enterprise initiatives tied to corporate strategy and operational excellence.

The ideal candidate is proactive, highly organized, analytically strong, and thrives in a fast-paced, highly visible environment. They combine executive presence with rigorous analysis, clear storytelling, and an ability to orchestrate alignment and execution across R&D, Manufacturing, Commercial, Finance, and G&A teams.

This role is based in Waltham, MA without the possibility of being a remote role.

Primary Responsibilities

Executive & Board Support

• Partner closely with executive leadership to plan, coordinate, and manage EC and Board agendas and operating rhythms
• Lead the development and refinement of EC/Board materials (presentations, dashboards, briefing documents, pre-reads) that are clear, concise, and decision-oriented
• Ensure leadership materials consistently highlight tradeoffs, risks, scenarios, dependencies, and recommendations
• Collaborate with HR and other stakeholders on leadership meeting design, cadence, and execution
• Prepare high-quality briefing materials, presentations, and reports for the CEO and executive team

Analytics, Insights & Enterprise Performance

• Synthesize complex, cross-functional data into executive-level insights, visualizations, and storylines that enable strategic choices and accountability
• Develop integrated views of performance, progress, risks, and dependencies using data from multiple functions; ensure consistency, accuracy, and relevance
• Elevate the use of analytics in EC/Board discussions by framing metrics in context (benchmarks, trends, thresholds) and proposing clear actions

Strategic Initiatives & Cross-Functional Leadership

• Lead enterprise-wide, high-priority initiatives that advance corporate strategy and operational priorities
• Establish project plans, milestones, owners, and success metrics; drive execution and accountability across teams
• Use data and insights to track progress, identify risks, and recommend course corrections; escalate issues with solutions
• Lead special initiatives requiring senior leadership engagement and cross-functional coordination

Process Excellence & Operating Rhythm Optimization

• Own and continuously improve the end-to-end process for EC and Board submissions (timelines, templates, standards, content expectations)
• Drive consistency and quality across leadership materials, including analytical rigor, visual clarity, and narrative coherence
• Identify and implement opportunities to streamline decision processes, operating rhythms, and cross-functional workflows to enhance organizational effectiveness

Stakeholder Engagement & Executive Communications

• Serve as a trusted liaison between executive leadership and functional teams to ensure alignment, transparency, and timely decision-making
• Foster strong relationships with internal stakeholders and Board members
• Draft and refine executive-level presentations and correspondence; support leaders with data-backed storytelling for leadership forums and internal communications

Qualifications

• Bachelor’s degree required; advanced degree (MBA, MS) preferred or equivalent practical experience
• 10+ years of relevant experience in Strategy & Operations, Corporate Strategy, Management Consulting, PMO/Transformation, or related roles; exp