Staff Scientist, R&D (Epigenomics)

Natera is seeking a highly skilled and innovative Staff Scientist to join our Molecular Biology Research Team. The Staff Scientist will conduct new product research to develop/refine methylation-based next-generation sequencing (NGS) technologies that advance Natera’s oncology diagnostic capabilities. In this role, you will independently lead projects to design, prototype, and optimize novel NGS methods and collaborate cross-functionally to move concepts from ideation to implementation. A successful candidate must have a strong background in molecular biology, substantial experience with NGS-based methylation detection, and a track record of successful research leadership in an industrial setting.

Responsibilities:

• Lead and manage the development of innovative NGS-based diagnostic assays from feasibility through optimization.

• Define project goals and plans with input from stakeholders and coordinate cross-functional efforts to meet milestones.

• Independently design and execute complex laboratory experiments; analyze and interpret results to guide research direction.

• Collaborate closely with bioinformatics, statistics, and data science teams to ensure robust experimental design and data analysis.

• Mentor and guide junior scientists while promoting scientific rigor and best practices.

• Author high-quality protocols, technical reports, and study documentation.

• Communicate progress regularly to stakeholders, including departmental meetings and senior leadership.

• Contribute to risk management, strategy development, and continuous improvement of scientific workflows.

Qualifications:

• Ph.D. in molecular biology, genomics, or a closely related field.

• Minimum 8 years of relevant industry experience, or 2+ years postdoctoral research with 6+ years in industry.

• Proven experience in designing and advancing NGS-based diagnostics, preferably in the field of oncology.

Knowledge, Skills, and Abilities:

• Extensive hands-on experience with NGS platforms, including sample prep, library prep, target enrichment (e.g., multiplex PCR, hybrid capture), and sequencing.

• Strong understanding of molecular biology techniques related to DNA/RNA manipulation and epigenomics/methylation detection.

• Proficient in statistical analysis tools such as Excel, JMP, R, or Python; familiarity with bioinformatics workflows is a plus.

• Ability to translate complex biological questions into actionable experiments and scalable solutions.

• Experience writing study plans, SOPs, and detailed reports.

• Excellent organizational, communication, and time management skills.

• Demonstrated ability to lead projects and contribute strategically to a team-driven research environment.

• Up-to-date knowledge of developments in oncology and genomic technologies.

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.San Carlos, CA $148,000—$185,050 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

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