Sr Research Associate/Research Associate, Protein Sciences

Programmable DNA, the software of Life, is finally here! Twist Bioscience is developing a disruptive Synthetic DNA technology that will change the world, enabling widespread health and sustainability. Synthetic biologists will use our products to engineer how organisms produce cures to diseases, make everyday chemicals by using the atmosphere as the carbon source, enable plants to make their own fertilizers, and to create in-vivo diagnostics that alert us when we are sick, and many more applications.

We are seeking an outstanding, innovative, and creative Senior Research Associate/Research Associate, Protein Sciences, to join our therapeutic antibody discovery effort.  This associate will play multiple roles within the Pharma group and will work within a team responsible for antibody discovery, engineering and production utilizing mammalian protein expression, purification, characterization, and stable cell line production.

What You’ll Be Doing

• Generate high-throughput transient transfection IgG production workflows in both HEK293 and CHO expression systems

• Perform protein production, purification, and characterization of diverse biologics, including bispecific and engineered antibodies for early-stage screening and preclinical research work

• Conduct mammalian cell culture and stable cell lines production to validate antibody production
• Characterization of purified material using mass spectrometry, light scattering, IEF, HPLC and other biophysical techniques to generate data package for lead finding, optimization, and developability assessment
• Enable and lead analytical antibody testing efforts (affinity, binning, purity)
• Generate target over-expressing cell lines for antibody discovery work
• Perform molecular cloning to generate constructs to express proteins.
• Plan, perform, analyze, and document laboratory experiments in support of antibody discovery
• Evaluate and support the implementation of new technologies
• Maintain laboratory instruments and logistics
• Work collaboratively under aggressive timelines
  
  

What You’ll Bring to the Team

• Your educational background includes a B.S./M.S. in cell biology, biochemistry, immunology, protein biochemistry, or related discipline and 2 -3 years of industry experience.  
• You are excited to learn new techniques and work collaboratively with others
• You thrive in a dynamic, quickly changing environment where we were work individually and on teams
• You have a point of view, value your independent thinking, and are low ego

Preferred Qualifications

• Ability to multitask and thrive in a fast-paced and challenging environment  
• Strong organization skills and proficiency in computer skills including various databases
• Excellent oral/written communication and interpersonal skills a must
• Extensive experience with molecular cloning, mammalian cell culture, stable cell line production, protein purification, protein characterization, HPLC, and HT instrumentation
• Excellent problem-solving capabilities
• Extraordinary attention to detail and planning
• Proficiency with Microsoft Word, Excel, and PowerPoint

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.

The base cash compensation for this California-based role is targeted at $75,000 - $85,010  + bonus + equity + benefits. Final compensation amounts are determined by multiple factors, including candidate skill, experience, expertise, and location and may vary from the amount listed above. Compensation may be different in other locations