Senior Scientist, Endpoints and Biometrics - Evinova

Job Title: Senior Scientist, Endpoints and Biometrics – Evinova
Location: Gaithersburg, MD

At AstraZeneca, we pride ourselves on crafting a collaborative culture that champions knowledge-sharing, ambitious thinking and innovation – ultimately providing employees with the opportunity to work across teams, functions and even the globe. 

Recognizing the importance of individualized flexibility, our ways of working allow employees to balance personal and work commitments while ensuring we continue to create a strong culture of collaboration and teamwork by engaging face-to-face in our offices 3 days a week. Our head office is purposely designed with collaboration in mind, providing space where teams can come together to strategize, brainstorm and connect on key projects. 

Are you ready to be part of the future of healthcare? Can you think big, be bold, and harness the power of digital and AI to tackle longstanding life sciences challenges?  Then Evinova, a global health tech business might be for you!  

Evinova is a health-tech business, accelerating the delivery of better health outcomes by propelling the life sciences sector forward in digital health, from the inside. Through our application of science-based expertise, evidence-led rigour, and human experience-driven insight, our digital solutions are deliberately designed so that everyone can reach better health outcomes together. Evinova is a health-tech business within the AstraZeneca Group.

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you’re our kind of person.

Digital health, the point at which healthcare, technology, data and analytics converge, is the subject of phenomenal promise, with the World Health Organisation believing it has the potential to improve health for everyone. At AstraZeneca, we’ve been working hard to make this a reality, with the years of experience we have accumulated enabling us to now embed digital health at scale across R&D. To achieve our goal of improving patient experience and outcomes AstraZeneca has Digital Health as one of the top 4 strategic priorities for the company, details on digital health strategy can be found here. Oncology is the largest therapeutic area within AstraZeneca and second highest cause of death globally, with AstraZeneca’s ambition to eliminate cancer as a cause of death.

Introduction to Role:

A Senior Scientist in the Evinova Endpoints team will be a subject matter expert on evidence generation and data management in support of existing and novel endpoints detailing the patient benefit of new medicines to contribute to the successful development and commercialization of new, innovative therapies and digital health solutions. The Scientist will be responsible for applying quantitative clinical programming for validation and exploratory analytics applied to data from biosensor/wearable data, clinical outcomes assessments (COAs), or any combination thereof, to inform identification and/or evaluation of symptoms, function, health-related quality of life, or other patient-centric concept of clinical benefit throughout the drug development lifecycle. Therapeutic areas will span oncology, cardiovascular, renal & metabolism, and Respiratory & Immunology, among others. The Scientist will be responsible for contributing to the development of a clinical data flow and management working in collaboration with product engineers. This includes but is not limited to contributing and executing analysis plans for evidence generation to inform clinical validity of endpoints. The role must work in partnerships with internal stakeholders (e.g. Strategy, Data Science, COA Measurement, Product) and external stakeholders, e.g., Global and Clinical Study Teams, and partners, to uphold patient-centricity, diversity and sustainability values and scientific rigor.

Accountabilities:

• Contribute to workstreams by programming psychometrics/clinimetrics/statistics to generate evidence of patients’ experience with treatment throughout the drug development lifecycle. (e.g. psychometric performance of the instrument, sensitivity/specificity of signal detection, construction of novel endpoints).
• Contribute to workstreams on clinical data flow and management.
• Contribute to the conduct and interpretation of psychometrics/clinimetrics or statistical analyses for the validation of novel endpoints leveraging data from clinical outcomes assessments (COA) including data from sensors/wearables in clinical trials including: develop analyses strategy, manipulate and v