Senior Clinical Research Associate

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!  

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics. 

Why Join Us? 

• Innovative Environment:  Help to pioneer advancements in cancer immunotherapy. 

• Collaborative Culture: Be part of a diverse team dedicated to your professional growth. 

• Global Impact:  Contribute to therapies that make a lasting impact on patients globally. 

Role Overview: 

We are seeking a Senior Clinical Research Associate (CRA) to support our Clinical Operations team. The Senior CRA will be responsible for overseeing clinical trial site management and monitoring activities to ensure compliance with ICH-GCP, regulatory requirements, and company SOPs. In this role, you will partner closely with clinical sites and cross-functional teams to support high-quality study execution, patient recruitment, and operational excellence across clinical trials. 

Reports to: Associate Director, Team Lead Site Operations 

Location: Fully Remote 

Salary Range: $120,000 to $135,000 

Basic Qualifications: 

• Bachelor’s degree in life sciences, nursing, or a related field  

• 4+ years of on-site monitoring experience within the pharmaceutical or biotechnology industry, including all clinical monitoring visit types  

• Strong knowledge of ICH-GCP, FDA, EMA, and applicable clinical trial regulations  

• Demonstrated experience managing clinical trial sites, monitoring activities, and clinical trial documentation  

• Proficiency with clinical trial systems and tools (e.g., CTMS, eTMF, Microsoft Office) 

Preferred Qualifications:  

• Experience in oncology clinical trials or related therapeutic areas  

• Advanced presentation, organizational, and stakeholder management skills  

• Experience mentoring or training junior CRAs and supporting cross-functional clinical operations activities  

• Demonstrated ability to drive quality, efficiency, and continuous improvement initiatives in clinical operations  

• Strong understanding of clinical trial recruitment strategies, data capture, and site engagement best practices  

• Experience contributing to global harmonization, process optimization, or operational innovation initiatives 

In this role you will: 

• Conduct all clinical monitoring activities, including site qualification, initiation, routine monitoring, and close-out visits  

• Support site feasibility, site selection, and ongoing site management activities throughout the clinical trial lifecycle  

• Review clinical trial progress, patient recruitment, and data quality metrics, and implement actions to support study objectives  

• Maintain accurate and timely monitoring documentation, including trip reports and trial master file records  

• Collaborate with vendors, clinical sites, and cross-functional teams to support study execution and operational compliance  

• Participate in investigator meetings, clinical trial documentation development, and study team meetings  

• Mentor junior CRA team members and contribute to continuous improvement of clinical operations processes and procedures 

Travel required: Willingness to travel up to 75%. Valid Driver's License preferable.  

Qualified candidates will participate in a structured interview process, which includes: 

• An initial recruiter phone screen (conducted via video) 

• A recruiter-facilitated introduction and interview with the hiring leader and key stakeholders (via video) 

• A final-stage interview, which may include an in-person meeting at our U.S. Headquarters in Houston, TX 

What do we offer?  

At Immatics, we believe in investing in our team’s health, safety and well-being. Here’s what you can expect