Senior Scientist, CMC Downstream Process Development

Who We Are:

Neurocrine Biosciences is a leading biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering, developing and commercializing life-changing treatments for patients with under-addressed neurological, psychiatric, endocrine and immunological disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, hyperphagia in patients with Prader-Willi syndrome, endometriosis* and uterine fibroids*, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For more than three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders, because you deserve brave science. For more information, visit neurocrine.com, and follow the company on LinkedIn, X, Facebook and YouTube. (*in collaboration with AbbVie)

About the Role:

We are seeking a highly motivated and detail-oriented Senior Scientist/Engineer to join our Biologics Process Development team and advance Neurocrine’s antibody and bioconjugate assets from early preclinical development through commercialization. This role will lead downstream process development activities at bench and pilot scales, while supporting scale-up, technology transfer and implementation at external manufacturing facilities. The successful candidate will bring deep technical knowledge and hands-on experience in purification technologies, biologics process development, bioconjugation process development, and manufacturing. Working in a collaborative, cross-functional environment, you will strengthen technical capabilities and contribute to the development of best-in-class biotherapeutics.

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Your Contributions (include, but are not limited to):

• Independently design and execute scalable purification process for Neurocrine biologics assets across diverse modalities including monoclonal antibody, bispecific, APC (antibody-peptide conjugate), AOC (antibody-oligonucleotide conjugate), and others

• Serve as a downstream process development subject matter expert, leading the selection, optimization and troubleshooting of chromatography resins and modalities (e.g., affinity, AEX, CEX, HIC, MMC), as well as filtration processes

• Support process scale-up, technology transfer initiatives, contract manufacturing activities and external interactions as assigned

• Contribute to the continued evolution and improvement of internal platform purification processes

• Drive documentation excellence by authoring and reviewing protocols, technical reports and raw data to ensure data quality and compliance

• Provide scientific analysis to support process development and program decisions

• Evaluate and implement improvements to enhance product quality and manufacturing consistency

• Identify process challenges and perform troubleshooting activities within assigned scope

• Promote and ensure a safe and co