Principal Scientist - Biophysical Characterization

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

The Material Science, Lab Planning and Execution (MS-LPE) group is part of the Translational Science and Diagnostics (TS/Dx) team. TS/Dx leads internal and external diagnostic research & development activities to support multiple disease areas of interest including hematological malignancies, inflammatory disease programs, neuroscience, cardiovascular, fibrosis, and solid tumor indications. The TS&Dx group integrates scientific and business insights of multiple functions to provide innovative solutions that will make precision medicine a reality for the patients and health care providers we serve .

The primary purpose of this position is to lead and conduct laboratory experiments for the biophysical characterization of protein reagents for use across multiple technology platforms, including but not limited to:  Flow cytometry, IHC, and immunoassays. In this role the individual will be responsible for collaborating and communicating across the organization to assure on-time delivery of high-quality characterized materials.

Position Responsibilities:

• Independently design, execute, and analyze laboratory experiments to assess the biophysical/binding properties of antibody and non-antibody protein reagents using BLI, SPR, and other technologies.
• Independently design and execute method development experiments for immunoassays.
• Works independently to interpret results, plan next steps, compile final data summaries, and present results to stakeholders.
• May lead projects and provide oversight of experimental design and data review for junior staff members.
• May lead scientific collaborations and/or contracted research as needed.
• Collaborate with internal stakeholders to understand project needs and relay information back to the group.
• May serve as a technical point of contact within the group.
• May lead innovation projects related to the biophysical characterization of protein reagents.
• Proactively advise and share knowledge with bench scientists, peers, and senior management.
• Troubleshoots assay problems and instrument malfunctions. 
• Maintains required training per BMS standard operating procedures.
• Maintains and completes notebooks and other documentation as per departmental guidelines.
• Achieves objectives in a manner consistent with the BMS Behaviors
• May lead or contribute to writing and presentation of findings in the form of posters, publications, and oral presentations (internal and external)

Basic Qualifications:

• Bachelor’s Degree
  • 8+ years of academic and / or industry experience

Or

• Master’s Degree
  • 6+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences 
  • 4+ years of academic and / or industry experience

Preferred Qualifications

• Advanced knowledge of BLI or SPR
• Advanced knowledge in the development and validation of regulated pharmacokinetic, immunogenicity, and biomarker immunoassays.
• Experience with antibody and non-antibody protein generation.
• Advanced knowledge of the drug discovery and development process.
• Excellent verbal and written communication skills and the ability to independently interpret and deliver results.
• Ability to effectively work across levels and functions with both internal and external stakeholders.  
• Excellent problem-solving skills.
• Experience overseeing junior colleagues.

If you come across a role that intrigues you