As a Scientist / Senior Scientist in the Translational Unit within RII RU, you will play a critical role in bridging preclinical target, asset validation, and early clinical proof-of-concept studies by designing and performing translational assays in human cells, tissues, and biofluids. 

This is a lab-based position with an anticipated 4-5 days per week on-site presence at the GSK-Upper Providence (USA) location.

Key responsibilities include:

• Work closely with colleagues in the Translational Unit and other RII RU lines (biology, clinical) to design, optimize, and execute preclinical studies to strengthen target-disease hypotheses and validate biomarkers.

• Develop and execute technologies related to extracellular vesicles (EVs) such as blood processing, EV isolation, magnetic bead-based immunocapture, nanoparticle analysis, flow cytometry, ELISA/MSD/Quanterix, Western/JESS, TaqMan, and digital PCR.

• Identify and progress collaborations with internal and external partners to leverage expertise and resources to support transcriptomics (RNA-Seq) and proteomics (LCMS).

• Provide technical and disease input into the translational strategy for one or more projects and influence project direction through interpretation and integration of relevant project data.

• Build translational expertise in technology and disease areas; act as a go-to expert on specific technologies and disease mechanisms.

• Work closely with preclinical statistics to ensure robust study design of experiments. 

• Troubleshoot assays and, when necessary, develop alternative approaches.

• Stay up to date with the latest scientific literature and emerging technologies relevant to translational research.

• Present findings to internal teams, stakeholders, and governance in a balanced, clear, and precise manner.

• Maintain accurate and detailed laboratory records in alignment with data integrity expectations and ensure compliance with all relevant protocols and safety guidelines.

• Ensure compliance with all applicable laws, regulations, and ethical standards in the conduct of translational research.

• Foster a culture of innovation, collaboration, and continuous learning within the translational research team and across the organization.

Why you?

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• MS with 2+ years or BS with 4+ years relevant work experience in molecular & cellular biology or related field.

• Experience in any of the following technical capabilities: bioassay development and analysis (ELISA/MSD/Quanterix), cell culture, flow cytometry, quantitative PCR, analytic methods, RNA sequencing, extracellular vesicles, and emerging technologies.

• Experience in scientific innovation demonstrated through contributions to drug discovery projects, publications, conferences, reports, technical documents, or patents.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Excellent problem-solving skills and ability to critically analyze scientific data.

• Strong written and verbal communication skills, with the ability to effectively present scientific findings to multidisciplinary internal and external stakeholders in a balanced, clear, and precise manner.

• Proven ability to balance priorities across multiple objectives while maintaining attention to detail and high-performance standards.

• Ability to work independently as well as collaboratively in a team-oriented environment.

• Experience in RII RU relevant disease mechanisms and pathways, preferably in hepatology (Steatotic Liver Disease), and the ability to apply this knowledge to translational research and biomarker development.

• Resourcefulness to access cutting-edge technologies, tools, reagents, biosamples, biomarker expertise, and research capabilities.

• Experience with bioinformatics tools for the interpretation of large-scale datasets.

• Familiarity with the design and execution of biomarker-driven clinical trials and the development of companion diagnostics.

• Knowledge of regulatory guidelines and compliance requirements related to translational research and clinical development.

GSK-LI

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