Senior Associate Scientist I, Isotope Production

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/

Summary

The Senior Associate Scientist I, Isotope Production will provide hands-on laboratory support for radiochemical and analytical work associated with isotope production programs at RayzeBio. This role will assist in the execution of experiments and process steps supporting the production of Actinium-225 through cyclotron irradiation of Radium-226 targets, under the guidance of senior scientific staff. The individual will contribute to radiochemical separations, data collection, and laboratory operations, gaining exposure to process development activities that support the translation of laboratory-scale concepts into scalable production processes for shielded hot cells and GMP manufacturing facilities.

Job Responsibilities

Essential duties and responsibilities include the following. Other duties may be assigned.

·         Participate in the experimental design for R&D radiochemical processes associated with the production, purification, and recovery of Actinium-225 and related isotopes, under the direction of senior scientists.

·         Execute the implementation of separation and purification methods using chromatography, precipitation, solvent extraction, and other radiochemical techniques.

·         Run process scale-up studies, transitioning from benchtop to process scale operations for shielded hot cell operations.

·         Perform hands-on laboratory work with radioactive materials, including alpha-emitting isotopes, following established radiological safety practices and procedures.

·         Help maintain process flow diagrams, equipment logs, standard operating procedures, and technical documentation.

·         Collaborate with engineering and scientific staff on process equipment setup, automation systems, and routine facility operations.

·         Independently execute target processing activities, radionuclide recovery tasks, waste handling, and basic process troubleshooting.

·         Assist with literature review and data gathering to support process improvement efforts.

·         Collect, organize, and perform basic analysis of experimental data using standard scientific methods, under supervision.

·         Support technology transfer activities by assisting with documentation and execution of transfer protocols.

·         Work with external vendors and business partners to install and maintain laboratory equipment.

·         Follow established procedures with attention to detail and contribute to a culture of scientific rigor and operational excellence.

·         Less than 5% of travel may be required.

Education and Experience

·         BS/MS in Radiochemistry, Chemistry, or a related scientific field, with 2+ years of direct experience with radioactive materials.

·         Additional cGMP and chemistry laboratory experience is preferred.

Skills and Qualifications

• Coursework or laboratory exposure to Actinium-225, Radium-226, Thorium-229, Thorium-228, Radium-224, or other alpha-emitting isotope systems is a plus.

• Willingness to work with hot cells, gloveboxes, shielded enclosures, and remote handling systems.

•  Basic familiarity with cyclotron-produced radioisotopes and post-irradiation target processing is preferred.

•  Prior experience with ion exchange chromatography, extraction chromatography, solvent extraction, or radionuclide recovery methods, analytical instrumentation such as HPGe spectroscopy, alpha spectroscopy, ICP-OES, ICP-MS, liquid scintillation counting, or related techniques is preferred.

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