Scientist, Cell Therapy and Immune Cell Engager Discovery Biology

Working with Us
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Position Responsibilities

The Cell Therapy and Immune Cell Engager Discovery Biology team is looking for an innovative, creative and driven drug discovery immunologist to help advance our discovery portfolio of anti-tumor cell therapies and immune cell engagers into the clinic.  The successful candidate will have experience in antigen target identification and expression validation as well as expertise in subsets of tumor associated immunity and the tumor microenvironment.  This scientist will work in a highly collaborative, fast-paced environment involving multiple teams across the company including predictive science, drug discovery, translational and clinical teams.  

Responsibilities include but are not limited to:

• Identification and validation of tumor antigens suitable for targeting by cell therapies and immune engagers; requires interfacing will multiple functional teams

• Understanding of tumor microenvironment specific restrictions on immune cell infiltration and function and development of novel concepts to overcome these using cell engineering approaches

• Independently conceive, develop and execute novel in vitro and ex vivo assays/models to evaluate cell therapy efficacy in the context of the tumor microenvironment

• Collaboration across multiple projects / roles in a matrixed environment and obtaining alignment across key stakeholders and different functional groups to drive decision making

• Designing and implementing critical studies required to drive hypothesis-driven research

• Anticipate the need for contingencies and demonstrate flexibility through development of alternative strategies

• Present project updates and recommendations to leadership teams across the company 

• May provide supervision of junior scientists

• Maintaining cutting edge knowledge of relevant research fields

Basic Qualifications:

• Bachelor’s Degree

  • 5+ years of academic and / or industry experience

Or

• Master’s Degree

  • 3+ years of academic and / or industry experience

Or

• Ph.D. or equivalent advanced degree in the Life Sciences

  • No experience necessary

Preferred Qualifications:

• Requires developed knowledge of the principles and concepts of biological sciences, immunology, bioengineering, or related discipline

• Experience with cellular therapy or immune engagers is an advantage

• Experience with tumor antigen targeting validation studies in an advantage

• Experience with cutting edge technologies typically employed to assess immune cell function including but not limited to subset of Luminex, MSD, IncuCyte-based assays, multi-parameter flow cytometry, T cell activation assays, myeloid cell functional assays, heterotypic cell cultures, imaging technologies, molecular characterization of gene expression and protein expression (e.g. Taqman, western blot, Citeseq etc) 

• Demonstration of in-depth, scientific-directed, innovative thinking

• Self-motivated and focused with project management-oriented thinking; able to work on multiple projects in a matrix environment

• Ability to work well as both team member and as individual contributor is essential

• Good communication skills for cross-functional, management and external interactions; excellent oral presentation skills are critical

• Requires strong organizational skills to ensure thorough and timely documentation of experiments, a